PMID- 36029121
OWN - NLM
STAT- MEDLINE
DCOM- 20221024
LR  - 20221102
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 199
IP  - 3
DP  - 2022 Nov
TI  - Impact of human leukocyte antigen mismatch on outcomes after unrelated bone 
      marrow transplantation in paediatric patients: A retrospective analysis by the 
      JSTCT HLA working group.
PG  - 392-400
LID - 10.1111/bjh.18425 [doi]
AB  - The impact of human leukocyte antigen (HLA) mismatching at the HLA-A, -B, -C, and 
      -DRB1 loci after unrelated bone marrow transplantation in paediatric patients 
      with haematological malignancies has not been fully examined. Here, we analysed 
      patients with haematological malignancies (all aged </=15 years; n = 1330) who 
      underwent a first unrelated bone marrow transplantation between 1993 and 2017 in 
      Japan. The results show that although an HLA mismatch was significantly 
      associated with a low relapse rate, it was also associated with higher 
      non-relapse mortality. There was a significant association between HLA mismatch 
      and low overall survival. Locus mismatch analysis revealed that, as in adults, an 
      HLA-C mismatch had a significant negative impact on survival; however, in 
      paediatric patients, an HLA-DRB1 mismatch did not have a negative impact, 
      although these HLA mismatch effects are weakened in recent cases. Taken together, 
      the results suggest that an HLA-matched donor should be the first candidate for 
      paediatric patients; however, for patients without a matched sibling or matched 
      unrelated donor, we can select an unrelated donor with a mismatch at HLA-DRB1 if 
      available.
CI  - (c) 2022 British Society for Haematology and John Wiley & Sons Ltd.
FAU - Kato, Itaru
AU  - Kato I
AUID- ORCID: 0000-0002-2932-4960
AD  - Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, 
      Japan.
FAU - Sakaguchi, Hirotoshi
AU  - Sakaguchi H
AD  - Children Cancer Center, National Center for Child Health and Development, Tokyo, 
      Japan.
FAU - Kato, Shunichi
AU  - Kato S
AD  - Department of Innovative Medicine, Division of Stem Cell Transplantation, Tokai 
      University School of Medicine, Isehara, Japan.
FAU - Sato, Maho
AU  - Sato M
AD  - Department of Hematology/Oncology, Osaka Women's and Children's Hospital, Osaka, 
      Japan.
FAU - Noguchi, Maiko
AU  - Noguchi M
AD  - Department of Pediatrics, National Hospital Organization Kyushu Cancer Center, 
      Fukuoka, Japan.
FAU - Yoshida, Nao
AU  - Yoshida N
AUID- ORCID: 0000-0002-3783-2121
AD  - Department of Hematology and Oncology, Children's Medical Center, Japanese Red 
      Cross Aichi Medical Center Nagoya First Hospital, Nagoya, Japan.
FAU - Koh, Katsuyoshi
AU  - Koh K
AD  - Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, 
      Japan.
FAU - Koike, Takashi
AU  - Koike T
AD  - Department of Pediatrics, Tokai University School of Medicine, Isehara, Japan.
FAU - Yanagimachi, Masakatsu
AU  - Yanagimachi M
AD  - Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, 
      Japan.
FAU - Kato, Keisuke
AU  - Kato K
AD  - Division of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, 
      Ibaraki, Japan.
FAU - Takahashi, Yoshiyuki
AU  - Takahashi Y
AD  - Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Fujita, Naoto
AU  - Fujita N
AD  - Department of Pediatrics, Hiroshima Red Cross Hospital & Atomic-bomb Survivors 
      Hospital, Hiroshima, Japan.
FAU - Sato, Atsushi
AU  - Sato A
AD  - Department of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Japan.
FAU - Hashii, Yoshiko
AU  - Hashii Y
AD  - Department of pediatrics, Osaka International Cancer Institute, Osaka, Japan.
FAU - Tabuchi, Ken
AU  - Tabuchi K
AD  - Division of Pediatrics, Tokyo Metropolitan Cancer and Infectious Disease Center 
      Komagome Hospital, Bureau of Social Welfare and Public Health, Tokyo Metropolitan 
      Government, Tokyo, Japan.
FAU - Atsuta, Yoshiko
AU  - Atsuta Y
AUID- ORCID: 0000-0003-4404-2870
AD  - Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
AD  - Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical 
      University School of Medicine, Nagakute, Japan.
FAU - Morishima, Satoko
AU  - Morishima S
AUID- ORCID: 0000-0002-7391-4271
AD  - Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology 
      (Second Department of Internal Medicine), Graduate School of Medicine, University 
      of the Ryukyus, Nishihara-cho, Japan.
FAU - Kanda, Junya
AU  - Kanda J
AUID- ORCID: 0000-0002-6704-3633
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220827
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Child
MH  - Humans
MH  - Bone Marrow Transplantation/methods
MH  - *Graft vs Host Disease
MH  - *Hematologic Neoplasms/therapy
MH  - Histocompatibility Testing
MH  - HLA Antigens
MH  - HLA-A Antigens
MH  - HLA-C Antigens
MH  - HLA-DRB1 Chains/genetics
MH  - Neoplasm Recurrence, Local
MH  - Retrospective Studies
MH  - Unrelated Donors
OTO - NOTNLM
OT  - HLA mismatch
OT  - haematological malignancy
OT  - paediatrics
OT  - unrelated bone marrow transplantation
EDAT- 2022/08/28 06:00
MHDA- 2022/10/22 06:00
CRDT- 2022/08/27 06:13
PHST- 2022/08/10 00:00 [revised]
PHST- 2022/06/28 00:00 [received]
PHST- 2022/08/11 00:00 [accepted]
PHST- 2022/08/28 06:00 [pubmed]
PHST- 2022/10/22 06:00 [medline]
PHST- 2022/08/27 06:13 [entrez]
AID - 10.1111/bjh.18425 [doi]
PST - ppublish
SO  - Br J Haematol. 2022 Nov;199(3):392-400. doi: 10.1111/bjh.18425. Epub 2022 Aug 27.