PMID- 3602969
OWN - NLM
STAT- MEDLINE
DCOM- 19870817
LR  - 20190908
IS  - 0355-3140 (Print)
IS  - 0355-3140 (Linking)
VI  - 13
IP  - 2
DP  - 1987 Apr
TI  - Occupational asthma caused by himic anhydride.
PG  - 150-4
AB  - Acid anhydride compounds are reactive chemicals that have been previously 
      associated with immunoglobulin E (IgE) mediated occupational asthma. Twenty 
      workers with exposure to himic anhydride powder used for the manufacture of a 
      synthetic flame retardant were questioned about respiratory symptoms. The study 
      was initiated after one individual from the plant developed asthma. A test for 
      serum-specific IgE to human serum albumin conjugates of himic anhydride, phthalic 
      anhydride, hexahydrophthalic anhydride and trimellitic anhydride was performed 
      for seven workers with respiratory symptoms associated with himic anhydride 
      exposure. Three of the seven symptomatic workers who reported wheezing at work 
      exhibited elevated specific IgE to two or more acid anhydride-human serum albumin 
      conjugates. Radioallergosorbent inhibition studies performed with sera containing 
      high levels of himic anhydride-human serum albumin specific IgE from a 
      symptomatic worker demonstrated cross-allergenicity between himic anhydride-human 
      serum albumin and hexahydrophthalic anhydride-human serum albumin allergenic 
      determinants. This study demonstrated that himic anhydride can elicit 
      IgE-mediated sensitization in the workplace.
FAU - Rosenman, K D
AU  - Rosenman KD
FAU - Bernstein, D I
AU  - Bernstein DI
FAU - O'Leary, K
AU  - O'Leary K
FAU - Gallagher, J S
AU  - Gallagher JS
FAU - D'Souza, L
AU  - D'Souza L
FAU - Bernstein, I L
AU  - Bernstein IL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Finland
TA  - Scand J Work Environ Health
JT  - Scandinavian journal of work, environment & health
JID - 7511540
RN  - 0 (Norbornanes)
RN  - 2746-19-2 (himic anhydride)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/*chemically induced/immunology
MH  - Chemical Phenomena
MH  - Chemistry
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Norbornanes/*adverse effects
MH  - Occupational Diseases/*chemically induced/immunology
MH  - Radioallergosorbent Test
EDAT- 1987/04/01 00:00
MHDA- 1987/04/01 00:01
CRDT- 1987/04/01 00:00
PHST- 1987/04/01 00:00 [pubmed]
PHST- 1987/04/01 00:01 [medline]
PHST- 1987/04/01 00:00 [entrez]
AID - 2068 [pii]
AID - 10.5271/sjweh.2068 [doi]
PST - ppublish
SO  - Scand J Work Environ Health. 1987 Apr;13(2):150-4. doi: 10.5271/sjweh.2068.