PMID- 36029758
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220908
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 234
DP  - 2022 Sep
TI  - Repair effect of photobiomodulation combined with human umbilical cord 
      mesenchymal stem cells on rats with acute lung injury.
PG  - 112541
LID - S1011-1344(22)00155-5 [pii]
LID - 10.1016/j.jphotobiol.2022.112541 [doi]
AB  - Acute lung injury (ALI) impaired the function of blood oxygen exchange function, 
      resulting in tissue hypoxia and patient death. Recently, human umbilical cord 
      mesenchymal stem cells (hUCMSCs) are thought to mitigate the effects of ALI, 
      which boosts researchers' interest in employing stem cell-based therapies to 
      manage ALI. However, as a novel therapy, hUCMSCs still face various limitations 
      such as migrating weakly and insufficient proliferation in vivo. 
      Photobiomodulation (PBM) effciently promotes cell proliferation, migration and 
      homing, which presents a promising strategy for overcoming above limitations. In 
      this study, PBM was emerged to intervene hUCMSCs through detecting cell 
      proliferation, oxidative stress-related factors and inflammatory factors. These 
      results assuredly confirmed that PBM enhanced the antioxidant capacity of cells 
      and improved cell survival in vitro experiments. In vivo, PBM-intervened hUCMSCs 
      intuitively reduce thickness of alveolar septum, excessive secretion of 
      inflammatory factors, relieves bleeding, edema and fibrosis. As a physical 
      intervention, PBM further strengthens the therapeutic effect of hUCMSCs and 
      depicted a hopeful therapy in ALI treatment.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Chen, Hongli
AU  - Chen H
AD  - State Key Laboratry of Separation Membrane and Membrane Process, Tiangong 
      University, Tianjin 300387, China; Tianjin Key Laboratory of Engineering 
      Technologies for Cell Pharmaceutical, National Engineering Research Center of 
      Cell Products, AmCellGene Co., Ltd., Tianjin 300457, China.
FAU - Cai, Yuanhao
AU  - Cai Y
AD  - State Key Laboratry of Separation Membrane and Membrane Process, Tiangong 
      University, Tianjin 300387, China.
FAU - Sun, Shujie
AU  - Sun S
AD  - State Key Laboratry of Separation Membrane and Membrane Process, Tiangong 
      University, Tianjin 300387, China.
FAU - Pan, Zhenhua
AU  - Pan Z
AD  - Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, 
      Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, 
      Tianjin 300052, China.
FAU - Han, Zhibo
AU  - Han Z
AD  - Tianjin Key Laboratory of Engineering Technologies for Cell Pharmaceutical, 
      National Engineering Research Center of Cell Products, AmCellGene Co., Ltd., 
      Tianjin 300457, China.
FAU - Liu, Pai
AU  - Liu P
AD  - State Key Laboratry of Separation Membrane and Membrane Process, Tiangong 
      University, Tianjin 300387, China. Electronic address: liupai@tiangong.edu.cn.
FAU - Liu, Yi
AU  - Liu Y
AD  - State Key Laboratry of Separation Membrane and Membrane Process, Tiangong 
      University, Tianjin 300387, China. Electronic address: yiliuchem@whu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220811
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
SB  - IM
MH  - *Acute Lung Injury/therapy
MH  - Animals
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation/methods
MH  - *Mesenchymal Stem Cells
MH  - Rats
MH  - Umbilical Cord
OTO - NOTNLM
OT  - Acute lung injury (ALI)
OT  - Human umbilical cord mesenchymal stem cells (hUCMSCs)
OT  - Oxidative
OT  - Photobiomodulation (PBM)
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/28 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/08/27 18:32
PHST- 2022/07/05 00:00 [received]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2022/08/28 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/08/27 18:32 [entrez]
AID - S1011-1344(22)00155-5 [pii]
AID - 10.1016/j.jphotobiol.2022.112541 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2022 Sep;234:112541. doi: 
      10.1016/j.jphotobiol.2022.112541. Epub 2022 Aug 11.