PMID- 36030074 OWN - NLM STAT- MEDLINE DCOM- 20220830 LR - 20220923 IS - 1532-1924 (Electronic) IS - 1521-6926 (Linking) VI - 35 IP - 1 DP - 2022 Mar TI - Treatment modalities in cancer-associated venous thromboembolism (VTE). PG - 101354 LID - S1521-6926(22)00009-3 [pii] LID - 10.1016/j.beha.2022.101354 [doi] AB - Anticoagulation is the cornerstone of cancer-associated VTE treatment, including vitamin K antagonists (VKA), unfractionated heparin (UFH), fondaparinux, low-molecular-weight heparins (LMWH) and direct oral anticoagulants (DOACs). The goals of anticoagulant therapy in cancer patients with cancer-associated thrombosis (CAT) are to improve symptoms, reduce risk of recurrent VTE or fatal pulmonary embolism (PE), and decrease the risk of post-thrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension. Although LMWH have been the standard of care for a long time for VTE treatment in cancer patients, showing superiority over the classic VKA, in the recent years the landscape of anticoagulant therapy has significantly changed with the inclusion of DOACs in this population. CI - Copyright (c) 2022. Published by Elsevier Ltd. FAU - Soto Alsar, Javier AU - Soto Alsar J AD - Medical Oncology Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain. FAU - Gutierrez Ortiz de la Tabla, Ana AU - Gutierrez Ortiz de la Tabla A AD - Medical Oncology Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain. FAU - Ortega Moran, Laura AU - Ortega Moran L AD - Medical Oncology Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain; Cancer & Thrombosis Section, Spanish Society of Medical Oncology (SEOM), Spain. FAU - Munoz Martin, Andres J AU - Munoz Martin AJ AD - Medical Oncology Department, Hospital General Universitario Gregorio Maranon, Universidad Complutense, Madrid, Spain; Cancer & Thrombosis Section, Spanish Society of Medical Oncology (SEOM), Spain. Electronic address: andresmunmar@hotmail.com. LA - eng PT - Journal Article PT - Review DEP - 20220620 PL - Netherlands TA - Best Pract Res Clin Haematol JT - Best practice & research. Clinical haematology JID - 101120659 RN - 0 (Anticoagulants) RN - 0 (Heparin, Low-Molecular-Weight) RN - 9005-49-6 (Heparin) SB - IM MH - Anticoagulants MH - Heparin MH - Heparin, Low-Molecular-Weight MH - Humans MH - *Neoplasms MH - *Venous Thromboembolism OTO - NOTNLM OT - Cancer-associated thrombosis OT - Direct-oral anticoagulants OT - Low-molecular weight heparins OT - Venous thromboembolism EDAT- 2022/08/28 06:00 MHDA- 2022/08/31 06:00 CRDT- 2022/08/27 21:05 PHST- 2022/06/16 00:00 [received] PHST- 2022/06/16 00:00 [accepted] PHST- 2022/08/27 21:05 [entrez] PHST- 2022/08/28 06:00 [pubmed] PHST- 2022/08/31 06:00 [medline] AID - S1521-6926(22)00009-3 [pii] AID - 10.1016/j.beha.2022.101354 [doi] PST - ppublish SO - Best Pract Res Clin Haematol. 2022 Mar;35(1):101354. doi: 10.1016/j.beha.2022.101354. Epub 2022 Jun 20.