PMID- 36033309
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 8
IP  - 8
DP  - 2022 Aug
TI  - SNHG20 promotes the development of laryngeal squamous cell carcinoma via 
      miR-342-3p/MTDH axis.
PG  - e10085
LID - 10.1016/j.heliyon.2022.e10085 [doi]
LID - e10085
AB  - Long noncoding RNAs (lncRNAs) are important players in laryngeal squamous cell 
      carcinoma (LSCC). However, the function of the long noncoding RNA small nucleolar 
      RNA host gene 20 (SNHG20) in LSCC is hardly known. We therefore analyzed the role 
      of this lncRNA in LSCC. Our data showed that SNHG20 was significantly 
      overexpressed in LSCC cell lines and human LSCC tissue. SNHG20 significantly 
      promoted cell proliferation, migration and invasion of LSCC cells. The actions of 
      SNHG20 are likely mediated by miR-342-3p expression, which results in increased 
      expression of MTDH. Finally, the results of in vivo models confirmed that SNHG20 
      promotes LSCC progression through modulating miR-342-3p and MTDH expression. 
      Taken together, our study demonstrates that SNHG20/miR-342-3p/MTDH axis 
      participates in LSCC progression.
CI  - (c) 2022 The Author(s).
FAU - Xie, Zuozhong
AU  - Xie Z
AD  - Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central 
      South University, Changsha, Hunan 410008, China.
AD  - Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, 
      Central South University, Changsha City, Hunan Province, 410013, China.
FAU - Xiang, Hong
AU  - Xiang H
AD  - Center for Experimental Medical Research, The Third Xiangya Hospital, Central 
      South University, Changsha City, Hunan Province, 410013, China.
FAU - Li, Jingkun
AU  - Li J
AD  - Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha City, Hunan Province, 410013, China.
FAU - Zhang, Xiaowei
AU  - Zhang X
AD  - Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, 
      Central South University, Changsha City, Hunan Province, 410013, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, 
      Central South University, Changsha City, Hunan Province, 410013, China.
FAU - Tan, Guolin
AU  - Tan G
AD  - Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, 
      Central South University, Changsha City, Hunan Province, 410013, China.
LA  - eng
PT  - Journal Article
DEP - 20220811
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC9399968
OTO - NOTNLM
OT  - Laryngeal squamous cell carcinoma (LSCC)
OT  - MTDH
OT  - SNHG20
OT  - miR-342-3p
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/30 06:00
MHDA- 2022/08/30 06:01
PMCR- 2022/08/11
CRDT- 2022/08/29 04:51
PHST- 2022/02/12 00:00 [received]
PHST- 2022/04/20 00:00 [revised]
PHST- 2022/07/21 00:00 [accepted]
PHST- 2022/08/29 04:51 [entrez]
PHST- 2022/08/30 06:00 [pubmed]
PHST- 2022/08/30 06:01 [medline]
PHST- 2022/08/11 00:00 [pmc-release]
AID - S2405-8440(22)01373-1 [pii]
AID - e10085 [pii]
AID - 10.1016/j.heliyon.2022.e10085 [doi]
PST - epublish
SO  - Heliyon. 2022 Aug 11;8(8):e10085. doi: 10.1016/j.heliyon.2022.e10085. eCollection 
      2022 Aug.