PMID- 36033330
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 8
IP  - 8
DP  - 2022 Aug
TI  - Application of a reversed-phase ionic liquid dispersive liquid-liquid 
      microextraction method for the extraction and preconcentration of domoic acid 
      from urine samples.
PG  - e10152
LID - 10.1016/j.heliyon.2022.e10152 [doi]
LID - e10152
AB  - A simple and efficient sample extraction and preconcentration method based on 
      reversed-phase ionic liquid dispersive liquid-liquid microextraction 
      (RP-IL-DLLME) had been developed and used to quantify the domoic acid in human 
      urine samples. The analysis was performed by ultra-performance liquid 
      chromatography and photodiode array detection. During the procedure, hydrophilic 
      ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate [C(4)mim] BF(4) as 
      dispersive solvent and NaOH solution was chosen as extraction solvent. Some 
      important parameters in the method were investigated to get high enrichment 
      factors. Under optimal conditions, the linearity of the method was in the range 
      of 0.1-10 ng mL(-1) and the correlation coefficient was above 0.9996. The 
      relative standard deviations (RSDs) of the developed methods for intra-day (n = 
      5) and inter-day (n = 5) precision ranged from 1.9 to 3.9%. Meanwhile, limit of 
      detection (LOD) was 0.03 ng mL(-1)(S/N = 3) and that of quantification (LOQ) was 
      0.1 ng mL(-1)(S/N = 10) with the enrichment factors (EF) being 230. Eventually, 
      the proposed method was successfully applied to the determination of Dominic acid 
      in human urine samples.
CI  - (c) 2022 The Author(s).
FAU - Wang, Qiao Feng
AU  - Wang QF
AD  - Medical School, Xi'an Peihua University, Xi'an, Shaanxi, 710199, China.
FAU - Liang, Li Jun
AU  - Liang LJ
AD  - Department of Pharmacy, South China Hospital of Shenzhen University, Shenzhen 
      Guangdong 518116, China.
FAU - Sun, Jiang Bing
AU  - Sun JB
AD  - Department of Pharmacy, South China Hospital of Shenzhen University, Shenzhen 
      Guangdong 518116, China.
FAU - Zhou, Jun
AU  - Zhou J
AD  - Department of Pharmacy, South China Hospital of Shenzhen University, Shenzhen 
      Guangdong 518116, China.
LA  - eng
PT  - Journal Article
DEP - 20220810
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC9404275
OTO - NOTNLM
OT  - Domoic acid
OT  - Ionic liquid
OT  - Reversed-phase dispersive liquid-liquid microextraction
OT  - Ultra-high-performance liquid chromatography
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/30 06:00
MHDA- 2022/08/30 06:01
PMCR- 2022/08/10
CRDT- 2022/08/29 04:51
PHST- 2022/01/08 00:00 [received]
PHST- 2022/02/15 00:00 [revised]
PHST- 2022/07/28 00:00 [accepted]
PHST- 2022/08/29 04:51 [entrez]
PHST- 2022/08/30 06:00 [pubmed]
PHST- 2022/08/30 06:01 [medline]
PHST- 2022/08/10 00:00 [pmc-release]
AID - S2405-8440(22)01440-2 [pii]
AID - e10152 [pii]
AID - 10.1016/j.heliyon.2022.e10152 [doi]
PST - epublish
SO  - Heliyon. 2022 Aug 10;8(8):e10152. doi: 10.1016/j.heliyon.2022.e10152. eCollection 
      2022 Aug.