PMID- 36033602
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 16
DP  - 2022
TI  - Opioidergic pathways and kisspeptin in the regulation of female reproduction in 
      mammals.
PG  - 958377
LID - 10.3389/fnins.2022.958377 [doi]
LID - 958377
AB  - Endogenous opioid peptides have attracted attention as critical neuropeptides in 
      the central mechanism regulating female reproduction ever since the discovery 
      that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), 
      which are also known as kisspeptin/neurokinin B/dynorphin (KNDy) neurons, play a 
      role as a master regulator of pulsatile gonadotropin-releasing hormone (GnRH) 
      release in mammals. In this study, we first focus on the role of dynorphin 
      released by KNDy neurons in the GnRH pulse generation. Second, we provide a 
      historical overview of studies on endogenous opioid peptides. Third, we discuss 
      how endogenous opioid peptides modulate tonic GnRH/gonadotropin release in female 
      mammals as a mediator of inhibitory internal and external cues, such as ovarian 
      steroids, nutritional status, or stress, on reproduction. Then, we discuss the 
      role of endogenous opioid peptides in GnRH surge generation in female mammals.
CI  - Copyright (c) 2022 Uenoyama, Tsuchida, Nagae, Inoue and Tsukamura.
FAU - Uenoyama, Yoshihisa
AU  - Uenoyama Y
AD  - Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, 
      Nagoya University, Nagoya, Japan.
FAU - Tsuchida, Hitomi
AU  - Tsuchida H
AD  - Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, 
      Nagoya University, Nagoya, Japan.
FAU - Nagae, Mayuko
AU  - Nagae M
AD  - Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, 
      Nagoya University, Nagoya, Japan.
FAU - Inoue, Naoko
AU  - Inoue N
AD  - Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, 
      Nagoya University, Nagoya, Japan.
FAU - Tsukamura, Hiroko
AU  - Tsukamura H
AD  - Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, 
      Nagoya University, Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220811
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC9404872
OTO - NOTNLM
OT  - GnRH pulse generator
OT  - GnRH surge generator
OT  - KNDy neurons
OT  - Kiss1
OT  - dynorphin
OT  - endogenous opioid peptides
OT  - enkephalin
OT  - beta-endorphin
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/30 06:00
MHDA- 2022/08/30 06:01
PMCR- 2022/01/01
CRDT- 2022/08/29 04:56
PHST- 2022/05/31 00:00 [received]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/08/29 04:56 [entrez]
PHST- 2022/08/30 06:00 [pubmed]
PHST- 2022/08/30 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2022.958377 [doi]
PST - epublish
SO  - Front Neurosci. 2022 Aug 11;16:958377. doi: 10.3389/fnins.2022.958377. 
      eCollection 2022.