PMID- 36034891
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Nigella sativa supplementation improves cardiometabolic indicators in population 
      with prediabetes and type 2 diabetes mellitus: A systematic review and 
      meta-analysis of randomized controlled trials.
PG  - 977756
LID - 10.3389/fnut.2022.977756 [doi]
LID - 977756
AB  - OBJECTIVE: Nigella sativa (N. sativa) from the family Ranunculaceae has medicinal 
      properties. Previous studies have reported promising findings showing that N. 
      sativa may benefit cardiometabolic health; however, current evidence on its 
      cardiometabolic effects on those with prediabetes and type 2 diabetes mellitus 
      (T2DM) is still unclear. Hence, we conducted a systematic review and 
      meta-analysis to assess the efficacy of N. sativa on cardiometabolic parameters 
      in population with prediabetes and T2DM. METHODS: PubMed/Medline, ISI Web of 
      Science, Scopus, and Cochrane library were systematically searched up to June 20, 
      2022. Meta-analyses using random-effects models were used. RESULTS: Eleven 
      randomized controlled trials (RCTs) were included in the meta-analysis. N. sativa 
      intervention resulted in significant changes in fasting plasma glucose (FPG), 
      hemoglobin A1c (HbA1c), total cholesterol (TC), low-density lipoprotein 
      cholesterol (LDL-C), c-reactive protein (CRP), and malondialdehyde (MDA), without 
      overall changes in glucose levels after oral glucose tolerance test (OGTT), 
      fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), 
      triglyceride, high-density lipoprotein cholesterol (HDL-C), and body mass index 
      (BMI) when compared with the control group. In subgroup analyses, N. sativa 
      supplementation enhanced serum levels of HDL-C in subjects with baseline HDL-C 
      lower than 40 mg/dL. Furthermore, HOMA-IR and BMI values decreased in the N. 
      sativa-supplemented group compared with the control group, when the length of 
      follow-up was more than 8 weeks and the dose was more than 1 g/day for N. sativa 
      supplementation, respectively. CONCLUSION: Our findings indicate that N. sativa 
      supplementation may effectively improve cardiometabolic profiles in individuals 
      with prediabetes and T2DM.
CI  - Copyright (c) 2022 Saadati, Naseri, Asbaghi, Abhari, Zhang, Li and Gan.
FAU - Saadati, Saeede
AU  - Saadati S
AD  - Department of Medicine, School of Clinical Sciences, Monash University, 
      Melbourne, VIC, Australia.
FAU - Naseri, Kaveh
AU  - Naseri K
AD  - Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Asbaghi, Omid
AU  - Asbaghi O
AD  - Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
FAU - Abhari, Khadijeh
AU  - Abhari K
AD  - Department of Food Science and Technology, National Nutrition and Food Technology 
      Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Zhang, Pangzhen
AU  - Zhang P
AD  - School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences, 
      University of Melbourne, Parkville, VIC, Australia.
FAU - Li, Hua-Bin
AU  - Li HB
AD  - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of 
      Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China.
FAU - Gan, Ren-You
AU  - Gan RY
AD  - Research Center for Plants and Human Health, Institute of Urban Agriculture, 
      National Agricultural Science and Technology Center, Chinese Academy of 
      Agricultural Sciences, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220811
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9403837
OTO - NOTNLM
OT  - Nigella sativa
OT  - cardiometabolic
OT  - diabetes mellitus
OT  - glycemic homeostasis
OT  - lipid profile
OT  - meta-analysis
OT  - prediabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/30 06:00
MHDA- 2022/08/30 06:01
PMCR- 2022/01/01
CRDT- 2022/08/29 05:16
PHST- 2022/06/24 00:00 [received]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/08/29 05:16 [entrez]
PHST- 2022/08/30 06:00 [pubmed]
PHST- 2022/08/30 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.977756 [doi]
PST - epublish
SO  - Front Nutr. 2022 Aug 11;9:977756. doi: 10.3389/fnut.2022.977756. eCollection 
      2022.