PMID- 36035131
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220830
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 13
DP  - 2022
TI  - Primary primitive neuroectodermal tumor of the cervix confirmed with molecular 
      analysis in a pregnant woman: A case report and literature review.
PG  - 871531
LID - 10.3389/fgene.2022.871531 [doi]
LID - 871531
AB  - Primary primitive neuroectodermal tumor (PNET) in the female tract is rare. 
      Recently, a case of cervical PNET was diagnosed in our hospital. A 29-year-old 
      pregnant woman presented with a cystic-solid cervical mass at the 7th week of 
      gestation. The mass grew rapidly during follow-up and ruptured at the 22nd week. 
      A biopsy was performed on the mass. Pathological examination revealed a malignant 
      neoplasm composed of small cells which exhibited positive immunohistochemical 
      (IHC) staining for CD99, SYN, and FLI1. Fluorescence in situ hybridization (FISH) 
      displayed the presence of EWS-FLI1 fusion gene resulting from the chromosomal 
      translocation t (11;22, q24;q12), which confirmed the diagnosis of cervical PNET. 
      The reverse transcription-polymerase chain reaction (RT-PCR) results showed type 
      2 EWS-FLI1 fusion occurred in this tumor, suggesting a poor prognosis. The 
      patient underwent surgical resection and was given adjuvant chemotherapy followed 
      by pelvic radiotherapy. PNET arising from the genital tract, especially in the 
      uterine cervix, is very rare and presents a diagnostic challenge. FISH and RT-PCR 
      analysis are helpful for the diagnosis of such a tumor at an unusual site, as in 
      the present case.
CI  - Copyright (c) 2022 Wei, Jianguo, Xiao and Pengpeng.
FAU - Wei, Ding
AU  - Wei D
AD  - Department of Gynecological Oncology, Tianjin Central Hospital of Gynecology and 
      Obstetrics, Tianjin, China.
FAU - Jianguo, Zhao
AU  - Jianguo Z
AD  - Department of Gynecological Oncology, Tianjin Central Hospital of Gynecology and 
      Obstetrics, Tianjin, China.
FAU - Xiao, Li
AU  - Xiao L
AD  - Department of Gynecological Oncology, Tianjin Central Hospital of Gynecology and 
      Obstetrics, Tianjin, China.
FAU - Pengpeng, Qu
AU  - Pengpeng Q
AD  - Department of Gynecological Oncology, Tianjin Central Hospital of Gynecology and 
      Obstetrics, Tianjin, China.
AD  - Clinical School of Obstetrics and Gynecology Center, Tianjin Medical University, 
      Tianjin, China.
LA  - eng
PT  - Case Reports
DEP - 20220810
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC9399424
OTO - NOTNLM
OT  - cervix
OT  - literature review
OT  - molecular analysis
OT  - pregnant woman
OT  - primary primitive neuroectodermal tumor
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/30 06:00
MHDA- 2022/08/30 06:01
PMCR- 2022/08/10
CRDT- 2022/08/29 05:19
PHST- 2022/02/08 00:00 [received]
PHST- 2022/06/27 00:00 [accepted]
PHST- 2022/08/29 05:19 [entrez]
PHST- 2022/08/30 06:00 [pubmed]
PHST- 2022/08/30 06:01 [medline]
PHST- 2022/08/10 00:00 [pmc-release]
AID - 871531 [pii]
AID - 10.3389/fgene.2022.871531 [doi]
PST - epublish
SO  - Front Genet. 2022 Aug 10;13:871531. doi: 10.3389/fgene.2022.871531. eCollection 
      2022.