PMID- 36038113
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20230130
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 81
DP  - 2022 Nov
TI  - Type 2 diabetes mellitus augments Parkinson's disease risk or the other way 
      around: Facts, challenges and future possibilities.
PG  - 101727
LID - S1568-1637(22)00169-6 [pii]
LID - 10.1016/j.arr.2022.101727 [doi]
AB  - About 10% of the adult population is living with type 2 diabetes mellitus (T2DM) 
      and 1% of the population over 60 years of age is suffering from Parkinson's 
      disease (PD). A school of thought firmly believes that T2DM, an age-related 
      disease, augments PD risk. Such relationship is reflected from the severity of PD 
      symptoms in drug naive subjects possessing T2DM. Onset of Parkinsonian feature in 
      case controls possessing T2DM corroborates the role of hyperglycemia in PD. A few 
      cohort, meta-analysis and animal studies have shown an increased PD risk owing to 
      insulin resistance. High fat diet and role of insulin signaling in the regulation 
      of sugar metabolism, oxidative stress, alpha-synuclein aggregation and accumulation, 
      inflammatory response and mitochondrial function in PD models and sporadic PD 
      further connect the two. Although little is reported about the implication of PD 
      in hyperglycemia and T2DM, a few studies have also contradicted. Ameliorative 
      effect of anti-diabetic drugs on Parkinsonian symptoms and vague outcome of 
      anti-PD medications in T2DM patients also suggest a link. The article reviews the 
      literature supporting augmented risk of one by the other, analysis of proof of 
      the concept, facts, challenges, future possibilities and standpoint on the 
      subject.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Faizan, Mohd
AU  - Faizan M
AD  - Toxicogenomics and Predictive Toxicology Laboratory, Systems Toxicology and 
      Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research 
      (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226 001, Uttar 
      Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 
      201 002, Uttar Pradesh, India.
FAU - Sarkar, Alika
AU  - Sarkar A
AD  - Toxicogenomics and Predictive Toxicology Laboratory, Systems Toxicology and 
      Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research 
      (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226 001, Uttar 
      Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 
      201 002, Uttar Pradesh, India.
FAU - Singh, Mahendra Pratap
AU  - Singh MP
AD  - Toxicogenomics and Predictive Toxicology Laboratory, Systems Toxicology and 
      Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research 
      (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226 001, Uttar 
      Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 
      201 002, Uttar Pradesh, India. Electronic address: mpsingh@iitr.res.in.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220828
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
RN  - 0 (Insulin)
RN  - 0 (alpha-Synuclein)
SB  - IM
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/complications/drug therapy/epidemiology
MH  - Humans
MH  - *Hyperglycemia
MH  - Insulin/therapeutic use
MH  - *Parkinson Disease/complications/drug therapy
MH  - alpha-Synuclein
OTO - NOTNLM
OT  - Clinical link
OT  - PD
OT  - Preclinical link
OT  - T2DM
COIS- Conflict of interest None.
EDAT- 2022/08/30 06:00
MHDA- 2022/10/19 06:00
CRDT- 2022/08/29 19:37
PHST- 2022/02/07 00:00 [received]
PHST- 2022/08/01 00:00 [revised]
PHST- 2022/08/24 00:00 [accepted]
PHST- 2022/08/30 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/08/29 19:37 [entrez]
AID - S1568-1637(22)00169-6 [pii]
AID - 10.1016/j.arr.2022.101727 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2022 Nov;81:101727. doi: 10.1016/j.arr.2022.101727. Epub 2022 Aug 
      28.