PMID- 36039271
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220831
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 7
DP  - 2022 Jul
TI  - Adiponectin Can Be an Early Predictable Marker for Type 2 Diabetes Mellitus and 
      Nephropathy.
PG  - e27308
LID - 10.7759/cureus.27308 [doi]
LID - e27308
AB  - Background Several studies have examined serum adiponectin concentrations in 
      prediabetes, newly diagnosed type 2 diabetes mellitus (T2DM), and other types of 
      diabetes associated with the risk of T2DM and diabetic nephropathy (DN); however, 
      the results to date are inconclusive. An aim of the current study is to determine 
      whether adiponectin is a useful marker for the earlier development of T2DM and 
      DN. Methodology This cross-sectional study included 400 subjects. Among the 
      subjects, 100 were prediabetes subjects, 200 were T2DM patients, and the 
      remaining 100 were healthy controls. The biochemical and clinical parameters of 
      all patients were analyzed and the data were recorded. Results The mean levels of 
      adiponectin were significantly lower in prediabetic subjects than in healthy 
      controls (3.22 +/- 0.98, 5.36 +/- 2.24, p = 0.0001**). Furthermore, the levels of 
      adiponectin were significantly higher in both the groups of T2DM patients when 
      compared to healthy controls (19.85 +/- 3.31, 11.83 +/- 3.01, and 5.36 +/- 2.24, p = 
      0.0001**). In both diabetic groups, adiponectin was positively correlated with 
      body mass index, glycated hemoglobin, insulin, homeostasis model assessment of 
      insulin resistance, and microalbuminuria, while negatively correlated with 
      estimated glomerular filtration rate. Interestingly, adiponectin had a reversed 
      correlation in the prediabetic group. Conclusion Based on the results, the 
      present study suggests that significantly decreased levels of serum adiponectin 
      in prediabetic subjects might be used as a variable marker for T2DM. Moreover, 
      adiponectin may useful for detecting the early onset of nephropathy, compared to 
      microalbumin, as its concentration was significantly elevated in patients who 
      were newly diagnosed with T2DM without nephropathy.
CI  - Copyright (c) 2022, Ganesh et al.
FAU - Ganesh, Veluri
AU  - Ganesh V
AD  - Biochemistry, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission's 
      Research Foundation (Deemed to be University), Salem, IND.
FAU - M, Murugan
AU  - M M
AD  - Biochemistry, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission's 
      Research Foundation (Deemed to be University), Salem, IND.
FAU - Palem, Siva Prasad
AU  - Palem SP
AD  - Biochemistry, JJM (Jagadguru Jayadeva Murugarajendra) Medical College and 
      Hospital, Davanagere, IND.
LA  - eng
PT  - Journal Article
DEP - 20220726
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9403389
OTO - NOTNLM
OT  - adiponectin
OT  - egfr
OT  - microalbumin
OT  - nephropathy
OT  - type 2 diabetes mellitus
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/08/31 06:00
MHDA- 2022/08/31 06:01
PMCR- 2022/07/26
CRDT- 2022/08/30 01:48
PHST- 2022/07/26 00:00 [accepted]
PHST- 2022/08/30 01:48 [entrez]
PHST- 2022/08/31 06:00 [pubmed]
PHST- 2022/08/31 06:01 [medline]
PHST- 2022/07/26 00:00 [pmc-release]
AID - 10.7759/cureus.27308 [doi]
PST - epublish
SO  - Cureus. 2022 Jul 26;14(7):e27308. doi: 10.7759/cureus.27308. eCollection 2022 
      Jul.