PMID- 36039920
OWN - NLM
STAT- MEDLINE
DCOM- 20230116
LR  - 20240320
IS  - 1464-5491 (Electronic)
IS  - 0742-3071 (Print)
IS  - 0742-3071 (Linking)
VI  - 40
IP  - 2
DP  - 2023 Feb
TI  - Sense of vitality is associated with cardiovascular events in type 2 diabetes 
      independently of traditional risk factors and arterial stiffness.
PG  - e14938
LID - 10.1111/dme.14938 [doi]
LID - e14938
AB  - AIMS: The aim of this study was to determine if single items in the quality of 
      life questionnaire short form 36 (SF36) were associated with cardiovascular 
      events in patients with type 2 diabetes mellitus (T2DM). METHODS: In 756 T2DM 
      patients (260 women) from the CARDIPP study, nine questions from the domains 
      vitality and well-being in SF36 were analysed. Patients, 55-66 years, were 
      recruited in 2005-2008 and followed up until 31 December 2018 for the incidence 
      of major adverse cardiovascular events (MACE), that is, myocardial infarction, 
      stroke or cardiovascular death. RESULTS: Median follow-up time: 11.6 years, 
      during which 119 (16%) MACE occurred. The SF36 items: 'seldom full of pep' (HR 
      1.2, 95% CI: 1.1-1.4, p = 0.006), 'seldom a lot of energy' (HR 1.3, 95%CI: 
      1.1-1.5, p < 0.001), 'worn out' (HR 1.2, 95%CI: 1.0-1.4, p = 0.020) and 'seldom 
      happy' (HR 1.2, 95%CI: 1.0-1.4, p = 0.012) were independent risk factors for MACE 
      in separate models, as well as male sex, diabetes duration, HbA(1c) , sagittal 
      abdominal diameter and aortic pulse wave velocity. The variables 'seldom full of 
      pep' and 'seldom a lot of energy' remained associated with MACE when conducting 
      separate analyses for sexes. Only 'seldom a lot of energy' remained associated 
      with MACE when all items from SF-36 were comprised in the same model. 
      CONCLUSIONS: One single question regarding energy levels from SF36 may be used as 
      an independent risk factor for cardiovascular events in T2DM patients in primary 
      care, for both men and women. This item may be included in future risk assessment 
      for use in clinical practice for cardiovascular risk stratification of T2DM 
      patients. TRIAL REGISTRATION: The study was registered in clinicaltrial.gov 
      (NCT01049737) in 14 January 2010.
CI  - (c) 2022 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on 
      behalf of Diabetes UK.
FAU - Vergara, Marta
AU  - Vergara M
AUID- ORCID: 0000-0001-5428-4588
AD  - Department of Health, Medicine and Caring Sciences, Faculty of Medicine and 
      Health Sciences, Linkoping University, Linkoping, Sweden.
FAU - Ostgren, Carl Johan
AU  - Ostgren CJ
AUID- ORCID: 0000-0003-1617-3179
AD  - Department of Health, Medicine and Caring Sciences, Faculty of Medicine and 
      Health Sciences, Linkoping University, Linkoping, Sweden.
FAU - Nystrom, Fredrik H
AU  - Nystrom FH
AUID- ORCID: 0000-0002-1680-1000
AD  - Department of Health, Medicine and Caring Sciences, Faculty of Medicine and 
      Health Sciences, Linkoping University, Linkoping, Sweden.
FAU - Israelsson, Hanna
AU  - Israelsson H
AUID- ORCID: 0000-0002-0125-9589
AD  - Department of Health, Medicine and Caring Sciences, Faculty of Medicine and 
      Health Sciences, Linkoping University, Linkoping, Sweden.
LA  - eng
SI  - ClinicalTrials.gov/NCT01049737
GR  - Medical Research Council in Southeast Sweden/
GR  - Futurum/
GR  - GE Healthcare/
GR  - The Swedish Heart-Lung Foundation/
GR  - King Gustaf V and Queen Victoria Freemason Foundation/
GR  - 12661/Swedish Research Council/
GR  - The County Council of Ostergotland and Linkoping University/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220830
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Vascular Stiffness
MH  - Pulse Wave Analysis
MH  - Quality of Life
MH  - Risk Factors
MH  - *Myocardial Infarction/epidemiology/etiology
MH  - *Cardiovascular Diseases/etiology/complications
PMC - PMC10947232
OTO - NOTNLM
OT  - cardiovascular diseases
OT  - diabetes mellitus
OT  - primary health care
OT  - quality of life
OT  - risk factors
OT  - type 2
COIS- The authors have no conflicts of interest to declare that are relevant to the 
      content of this article.
EDAT- 2022/08/31 06:00
MHDA- 2023/01/17 06:00
PMCR- 2024/03/18
CRDT- 2022/08/30 07:03
PHST- 2022/06/09 00:00 [revised]
PHST- 2021/08/25 00:00 [received]
PHST- 2022/07/26 00:00 [accepted]
PHST- 2022/08/31 06:00 [pubmed]
PHST- 2023/01/17 06:00 [medline]
PHST- 2022/08/30 07:03 [entrez]
PHST- 2024/03/18 00:00 [pmc-release]
AID - DME14938 [pii]
AID - 10.1111/dme.14938 [doi]
PST - ppublish
SO  - Diabet Med. 2023 Feb;40(2):e14938. doi: 10.1111/dme.14938. Epub 2022 Aug 30.