PMID- 36040389
OWN - NLM
STAT- MEDLINE
DCOM- 20221021
LR  - 20230427
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 21
IP  - 10
DP  - 2022 Oct
TI  - Production of MHCII-expressing classical monocytes increases during aging in mice 
      and humans.
PG  - e13701
LID - 10.1111/acel.13701 [doi]
LID - e13701
AB  - Aging is associated with increased monocyte production and altered monocyte 
      function. Classical monocytes are heterogenous and a shift in their subset 
      composition may underlie some of their apparent functional changes during aging. 
      We have previously shown that mouse granulocyte-monocyte progenitors (GMPs) 
      produce "neutrophil-like" monocytes (NeuMo), whereas monocyte-dendritic cell 
      progenitors (MDPs) produce monocyte-derived dendritic cell (moDC)-producing 
      monocytes (DCMo). Here, we demonstrate that classical monocytes from the bone 
      marrow of old male and female mice have higher expression of DCMo signature genes 
      (H2-Aa, H2-Ab1, H2-Eb1, Cd74), and that more classical monocytes express MHCII 
      and CD74 protein. Moreover, we show that bone marrow MDPs and classical monocytes 
      from old mice yield more moDC. We also demonstrate higher expression of Aw112010 
      in old monocytes and that Aw112010 lncRNA activity regulates MHCII induction in 
      macrophages, which suggests that elevated Aw112010 levels may underlie increased 
      MHCII expression during monocyte aging. Finally, we show that classical monocyte 
      expression of MHCII is also elevated during healthy aging in humans. Thus, 
      aging-associated changes in monocyte production may underlie altered monocyte 
      function and have implications for aging-associated disorders.
CI  - (c) 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & 
      Sons Ltd.
FAU - Barman, Pijus K
AU  - Barman PK
AD  - Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 
      Los Angeles, California, USA.
AD  - Research Division of Immunology in the Department of Biomedical Sciences, 
      Cedars-Sinai Medical Center, Los Angeles, California, USA.
FAU - Shin, Juliana E
AU  - Shin JE
AD  - Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 
      Los Angeles, California, USA.
AD  - Research Division of Immunology in the Department of Biomedical Sciences, 
      Cedars-Sinai Medical Center, Los Angeles, California, USA.
FAU - Lewis, Sloan A
AU  - Lewis SA
AD  - Department of Molecular Biology and Biochemistry, University of California, 
      Irvine, California, USA.
AD  - Institute for Immunology, University of California, Irvine, California, USA.
FAU - Kang, Seokjo
AU  - Kang S
AD  - Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 
      Los Angeles, California, USA.
AD  - Research Division of Immunology in the Department of Biomedical Sciences, 
      Cedars-Sinai Medical Center, Los Angeles, California, USA.
FAU - Wu, Di
AU  - Wu D
AD  - Applied Genomics, Computation and Translational Core, Cedars-Sinai Cancer, 
      Cedars-Sinai Medical Center, Los Angeles, California, USA.
FAU - Wang, Yizhou
AU  - Wang Y
AD  - Applied Genomics, Computation and Translational Core, Cedars-Sinai Cancer, 
      Cedars-Sinai Medical Center, Los Angeles, California, USA.
FAU - Yang, Xiaoming
AU  - Yang X
AD  - Department of Pathology, Microbiology and Immunology, School of Medicine, 
      University of South Carolina, Columbia, South Carolina, USA.
FAU - Nagarkatti, Prakash S
AU  - Nagarkatti PS
AD  - Department of Pathology, Microbiology and Immunology, School of Medicine, 
      University of South Carolina, Columbia, South Carolina, USA.
FAU - Nagarkatti, Mitzi
AU  - Nagarkatti M
AD  - Department of Pathology, Microbiology and Immunology, School of Medicine, 
      University of South Carolina, Columbia, South Carolina, USA.
FAU - Messaoudi, Ilhem
AU  - Messaoudi I
AD  - Department of Molecular Biology and Biochemistry, University of California, 
      Irvine, California, USA.
AD  - Institute for Immunology, University of California, Irvine, California, USA.
AD  - Department of Microbiology, Immunology and Molecular Genetics in the College of 
      Medicine, University of Kentucky, Lexington, Kentucky, USA.
FAU - Benayoun, Berenice A
AU  - Benayoun BA
AUID- ORCID: 0000-0002-7401-4777
AD  - Leonard Davis School of Gerontology, University of Southern California, Los 
      Angeles, California, USA.
AD  - Molecular and Computational Biology Department, USC Dornsife College of Letters, 
      Arts and Sciences, University of Southern California, Los Angeles, California, 
      USA.
AD  - Biochemistry and Molecular Medicine Department, USC Keck School of Medicine, 
      University of Southern California, Los Angeles, California, USA.
FAU - Goodridge, Helen S
AU  - Goodridge HS
AUID- ORCID: 0000-0001-8097-2413
AD  - Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 
      Los Angeles, California, USA.
AD  - Research Division of Immunology in the Department of Biomedical Sciences, 
      Cedars-Sinai Medical Center, Los Angeles, California, USA.
LA  - eng
GR  - P01 AT003961/AT/NCCIH NIH HHS/United States
GR  - R01 ES030144/ES/NIEHS NIH HHS/United States
GR  - R01 AI134987/AI/NIAID NIH HHS/United States
GR  - R01 AA028735/AA/NIAAA NIH HHS/United States
GR  - UL1 TR001414/TR/NCATS NIH HHS/United States
GR  - R01 AI123947/AI/NIAID NIH HHS/United States
GR  - R01 AI152258/AI/NIAID NIH HHS/United States
GR  - R01 AI145910/AI/NIAID NIH HHS/United States
GR  - P20 GM103641/GM/NIGMS NIH HHS/United States
GR  - R21 AI143301/AI/NIAID NIH HHS/United States
GR  - F31 AA028704/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20220830
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Cell Differentiation
MH  - Dendritic Cells
MH  - Macrophages
MH  - *Monocytes/metabolism
MH  - *RNA, Long Noncoding/metabolism
MH  - Histocompatibility Antigens Class II
PMC - PMC9577948
OTO - NOTNLM
OT  - aging
OT  - bone marrow progenitors
OT  - monocytes
COIS- The authors declare that they have no competing interests.
EDAT- 2022/08/31 06:00
MHDA- 2022/10/20 06:00
PMCR- 2022/10/01
CRDT- 2022/08/30 10:36
PHST- 2022/07/11 00:00 [received]
PHST- 2022/08/05 00:00 [accepted]
PHST- 2022/08/31 06:00 [pubmed]
PHST- 2022/10/20 06:00 [medline]
PHST- 2022/08/30 10:36 [entrez]
PHST- 2022/10/01 00:00 [pmc-release]
AID - ACEL13701 [pii]
AID - 10.1111/acel.13701 [doi]
PST - ppublish
SO  - Aging Cell. 2022 Oct;21(10):e13701. doi: 10.1111/acel.13701. Epub 2022 Aug 30.