PMID- 36041600 OWN - NLM STAT- MEDLINE DCOM- 20221020 LR - 20221020 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 851 IP - Pt 2 DP - 2022 Dec 10 TI - Association between trimester-specific exposure to thirteen endocrine disrupting chemicals and preterm birth: Comparison of three statistical models. PG - 158236 LID - S0048-9697(22)05335-9 [pii] LID - 10.1016/j.scitotenv.2022.158236 [doi] AB - BACKGROUND: Growing evidence indicated that maternal exposure to some endocrine disrupting chemicals (EDCs) may increase the risk of preterm birth (PTB). However, few studies have evaluated the joint effect of EDCs on PTB. OBJECTIVES: This study aimed to evaluate the associations of maternal EDCs mixture in the 1st, 2nd, and 3rd trimesters during pregnancy with PTB, and identify the vital components that mainly contribute to PTB. METHODS: This study included 847 pregnant women that provided urine samples for all three trimesters. Urinary concentrations of thirteen EDC metabolites (four phthalates, two parabens, three phenols, and four benzotriazoles and benzothiazoles) were examined. Logistic regression model, quantile g-computation and Bayesian kernel machine regression (BKMR) models were applied to study the association. RESULTS: Logistic regression model suggested that only bisphenol A (BPA) in the 1st trimester significantly increased the OR of PTB after adjusting for BPA exposure in the 2nd and 3rd trimesters. Quantile g-computation model identified that urinary EDCs mixture in the 1st trimester were positively associated with PTB [OR (95 % CI): 1.98 (1.10, 3.58)], and the most heavily weighted component for PTB was BPA (26 %), followed by mono-2ethylhexyl phthalate (MEHP) (22 %). BKMR model determined a significant association between EDCs mixture in the 1st trimester and PTB when all EDC concentrations were at or above their 55th percentile compared with the median. The BKMR model found that BPA and MEHP were associated with an increase in the estimated probability of PTB, when the other EDCs were held to their 50th and 75th percentiles, respectively, in the 1st trimester. CONCLUSIONS: The results of mixture analysis models indicated that exposure to higher EDCs mixture in the 1st trimester may increase the risk of PTB. BPA was considered as the most contributing factor for PTB among the detected EDCs. CI - Copyright (c) 2022. Published by Elsevier B.V. FAU - Chen, Yingyu AU - Chen Y AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: yychanatm@hust.edu.cn. FAU - Xiao, Han AU - Xiao H AD - Institute of Maternal and Child Health, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: tjxiaohan@hust.edu.cn. FAU - Namat, Asmagvl AU - Namat A AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Liu, Juan AU - Liu J AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: liujuan19@hust.edu.cn. FAU - Ruan, Fengyu AU - Ruan F AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. FAU - Xu, Shunqing AU - Xu S AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: xust@hust.edu.cn. FAU - Li, Ruizhen AU - Li R AD - Department of Child Health Care, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: dz_lrz@163.com. FAU - Xia, Wei AU - Xia W AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: xiawei@hust.edu.cn. LA - eng PT - Journal Article DEP - 20220827 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Endocrine Disruptors) RN - 0 (Parabens) RN - FU2EWB60RT (mono-(2-ethylhexyl)phthalate) RN - 0 (Environmental Pollutants) RN - MLT3645I99 (bisphenol A) RN - 6O7F7IX66E (phthalic acid) RN - 0 (Phthalic Acids) RN - 0 (Phenols) RN - 0 (Benzothiazoles) SB - IM MH - Infant, Newborn MH - Female MH - Pregnancy MH - Humans MH - *Endocrine Disruptors/adverse effects/urine MH - Parabens MH - *Premature Birth/chemically induced/epidemiology MH - Bayes Theorem MH - *Environmental Pollutants/urine MH - *Phthalic Acids/urine MH - Phenols/toxicity/urine MH - Maternal Exposure MH - Models, Statistical MH - Benzothiazoles OTO - NOTNLM OT - Endocrine disrupting chemicals (EDCs) OT - Mixture modeling OT - Preterm birth OT - Trimester COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/08/31 06:00 MHDA- 2022/10/21 06:00 CRDT- 2022/08/30 19:25 PHST- 2022/06/05 00:00 [received] PHST- 2022/08/19 00:00 [revised] PHST- 2022/08/19 00:00 [accepted] PHST- 2022/08/31 06:00 [pubmed] PHST- 2022/10/21 06:00 [medline] PHST- 2022/08/30 19:25 [entrez] AID - S0048-9697(22)05335-9 [pii] AID - 10.1016/j.scitotenv.2022.158236 [doi] PST - ppublish SO - Sci Total Environ. 2022 Dec 10;851(Pt 2):158236. doi: 10.1016/j.scitotenv.2022.158236. Epub 2022 Aug 27.