PMID- 36042606
OWN - NLM
STAT- MEDLINE
DCOM- 20220901
LR  - 20221115
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 101
IP  - 34
DP  - 2022 Aug 26
TI  - 68Ga-DOTATATE PET/CT imaging for insulinoma in MEN1 patient with endogenous 
      hyperinsulinemic hypoglycemia: A case report.
PG  - e30252
LID - 10.1097/MD.0000000000030252 [doi]
LID - e30252
AB  - RATIONALE: Multiple endocrine neoplasia type 1 (MEN1) syndrome is a rare and 
      complicated disease that is associated with several endocrine tumors. Here, we 
      report a case of MEN1 associated with insulinoma, parathyroid, and pituitary 
      tumors by 68Ga-DOTATATE positron emission tomography/computed tomography 
      (PET/CT). PATIENT CONCERNS: A 49-year-old woman presented with intermittent 
      hypoglycemia for more than a year and developed indistinct consciousness without 
      an apparent trigger. DIAGNOSES: Biochemical results showed abnormally high serum 
      insulin and parathyroid hormone levels. She underwent an Abdominal magnetic 
      resonance imaging revealed a small nodule in the uncinate process of the 
      pancreas, but it did not clarify the nature of the small nodule. Pituitary 
      magnetic resonance imaging scan revealed a micropituitary tumor, and parathyroid 
      imaging showed no abnormalities. 18F-FDG PET/CT showed no apparent abnormal 
      18F-FDG uptake in the whole body. In contrast, 68Ga-DOTATATE PET/CT imaging 
      showed pathological radiotracer uptake in the pancreatic uncinate process, 
      accompanied by mild radiotracer uptake in the pituitary gland, and no apparent 
      abnormal radiotracer uptake in the parathyroid area. INTERVENTIONS: The patient 
      underwent echoendoscopy for pancreatic uncinate process lesions and surgical 
      resection. OUTCOMES: Histological analysis was suggested of insulinoma of 
      pancreatic neuroendocrine tumor, the Ki-67 index was low (only 1% being 
      positive). LESSONS: This case demonstrates that 68Ga-DOTATATE can be used for the 
      detection of MEN1-related tumors and preoperative localization of small and 
      low-grade insulinomas by PET/CT.
CI  - Copyright (c) 2022 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Liu, Yunuan
AU  - Liu Y
AD  - Department of Nuclear Medicine, The Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, China.
FAU - Zhao, Xinming
AU  - Zhao X
FAU - Zhang, Jingmian
AU  - Zhang J
FAU - Wang, Jianfang
AU  - Wang J
FAU - Zhang, Zhaoqi
AU  - Zhang Z
FAU - Dai, Meng
AU  - Dai M
FAU - Wang, Na
AU  - Wang N
FAU - Jing, Fenglian
AU  - Jing F
FAU - Wang, Tingting
AU  - Wang T
FAU - Tian, Weiwei
AU  - Tian W
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Organometallic Compounds)
RN  - 0 (copper dotatate CU-64)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - *Congenital Hyperinsulinism
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - *Insulinoma/complications/diagnostic imaging
MH  - Middle Aged
MH  - *Multiple Endocrine Neoplasia Type 1/complications/diagnostic imaging
MH  - *Organometallic Compounds
MH  - *Pancreatic Neoplasms/complications/diagnostic imaging/pathology
MH  - Positron Emission Tomography Computed Tomography/methods
MH  - Positron-Emission Tomography
MH  - Radionuclide Imaging
PMC - PMC9410581
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2022/09/01 06:00
MHDA- 2022/09/02 06:00
PMCR- 2022/08/26
CRDT- 2022/08/31 01:11
PHST- 2022/08/31 01:11 [entrez]
PHST- 2022/09/01 06:00 [pubmed]
PHST- 2022/09/02 06:00 [medline]
PHST- 2022/08/26 00:00 [pmc-release]
AID - 00005792-202208260-00025 [pii]
AID - 10.1097/MD.0000000000030252 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2022 Aug 26;101(34):e30252. doi: 
      10.1097/MD.0000000000030252.