PMID- 36042671 OWN - NLM STAT- MEDLINE DCOM- 20220901 LR - 20221207 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 101 IP - 34 DP - 2022 Aug 26 TI - Clinical significance of hepatic function in Graves disease with type 2 diabetic mellitus: A single-center retrospective cross-sectional study in Taiwan. PG - e30092 LID - 10.1097/MD.0000000000030092 [doi] LID - e30092 AB - Graves disease (GD) and type 2 diabetes mellitus (T2DM) both impair liver function; we therefore explored the possibility of a relationship among diabetic control, thyroid function, and liver function. This retrospective, cross-sectional study compared serum liver function biomarkers of primary GD patients in a single center between 2016 and 2020, derived from clinical databases, and clarified the correlation of liver function in GD patients with or without T2DM. Furthermore, the diabetes mellitus group was divided into glycated hemoglobin A1C (HbA1C) <6.5% group and >/=6.5% group to further analyze the effect by disease control in patients. Statistical differences between groups were assessed using independent t tests to clarify the association of serum biomarkers between GD with T2DM. Pearson test was applied to assess within-group statistical correlation of serum biomarkers. The correlation of factors in each group was demonstrated by using the Kendall tau-b method and stepwise regression analysis. A total of 77 patients were included in the study. In the study population, glutamate pyruvate transaminase (GPT) was significantly correlated with thyroid-stimulating hormone, and HbA1C was significantly correlated with alkaline phosphatase (ALK-P), glutamate oxaloacetate transaminase (GOT), and GPT. An examination of GOT, GPT, free thyroxine (FT4), and HbA1C levels revealed a significant difference between the non-T2DM and T2DM groups. GPT also exhibited a significant correlation with triiodothyronine in the T2DM group. The T2DM group was further divided into groups: HbA1C <6.5% and >/=6.5%. The results demonstrated that ALK-P, GOT, GPT, and FT4 levels were significantly different between the groups. A significant correlation between ALK-P and thyroid-stimulating hormone and between GOT and FT4 was also identified in the HbA1C <6.5% group. Our single-center study revealed that diabetes affects liver function in patients with GD. For patients with T2DM, when liver function becomes impaired, thyroid function control deteriorates. GPT was correlated with triiodothyronine but not with FT4, which indicated the impairment of deiodination in the liver. This phenomenon was not observed in the non-T2DM population. The early detection of abnormal liver function in patients with GD and T2DM may help limit the development of comorbidities and improve disease management. CI - Copyright (c) 2022 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Lee, Yi-Wei AU - Lee YW AD - Department of Internal Medicine, Taipei Medical University Hospital, Taiwan. FAU - Lin, Yan-Yu AU - Lin YY AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan. FAU - Weng, Shuen-Fu AU - Weng SF AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan. AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan. FAU - Hsu, Chung-Huei AU - Hsu CH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan. AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taiwan. FAU - Huang, Chen-Ling AU - Huang CL AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan. FAU - Lin, Yu-Pei AU - Lin YP AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taiwan. FAU - Hsieh, Yu-Shan AU - Hsieh YS AUID- ORCID: 0000-0001-7726-3819 AD - School of Nursing, National Taipei University of Nursing and Health Sciences, Taiwan. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Biomarkers) RN - 0 (Glutamates) RN - 0 (Glycated Hemoglobin A) RN - 06LU7C9H1V (Triiodothyronine) RN - 9002-71-5 (Thyrotropin) RN - EC 2.6.1.1 (Aspartate Aminotransferases) RN - EC 2.6.1.2 (Alanine Transaminase) RN - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases) RN - Q51BO43MG4 (Thyroxine) SB - IM MH - Alanine Transaminase MH - Aspartate Aminotransferases MH - Biomarkers MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2 MH - Glutamates MH - Glycated Hemoglobin MH - *Graves Disease/complications MH - Humans MH - Receptor Protein-Tyrosine Kinases MH - Retrospective Studies MH - Taiwan/epidemiology MH - Thyrotropin MH - Thyroxine MH - Triiodothyronine PMC - PMC9410657 COIS- The authors have no conflicts of interest to disclose. All the authors declare that they have no conflict of interest with any organization that sponsored the research. EDAT- 2022/09/01 06:00 MHDA- 2022/09/02 06:00 PMCR- 2022/08/26 CRDT- 2022/08/31 01:11 PHST- 2022/08/31 01:11 [entrez] PHST- 2022/09/01 06:00 [pubmed] PHST- 2022/09/02 06:00 [medline] PHST- 2022/08/26 00:00 [pmc-release] AID - 00005792-202208260-00090 [pii] AID - 10.1097/MD.0000000000030092 [doi] PST - ppublish SO - Medicine (Baltimore). 2022 Aug 26;101(34):e30092. doi: 10.1097/MD.0000000000030092.