PMID- 36043339
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230208
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 95
IP  - 1
DP  - 2023 Jan
TI  - A significant predictor of in-hospital and long-term mortality and progression in 
      COVID-19 patients: The end-stage liver disease (MELD) score model.
PG  - e28109
LID - 10.1002/jmv.28109 [doi]
AB  - The aim of this study is to investigate the relationship between the model for 
      end-stage liver disease (MELD) score and disease progression and mortality in 
      COVID-19 patients. The files of 4213 patients over the age of 18 who were 
      hospitalized with the diagnosis of COVID-19 between March 20, 2020 and May 1, 
      2021 were retrospectively scanned. Sociodemographic characteristics, chronic 
      diseases, hemogram and biochemical parameters at the time they were diagnosed 
      with COVID-19 of the patients, duration of hospitalization, duration of intensive 
      care unit (ICU), duration of intubation, in-hospital mortality from COVID-19 and 
      outside-hospital mortality for another reason (within the last 1 year) and 
      recurrent hospitalization (within the last 1 year) were recorded. The MELD scores 
      of the patients were calculated. Two groups were formed as MELD score < 10 and 
      MELD score >/= 10. The rate of ICU, in-hospital mortality from COVID-19 and 
      outside-hospital mortality from other causes, intubation rate, and recurrent 
      hospitalization were significantly higher in the MELD >/= 10 group. The duration of 
      ICU, hospitalization, intubation were significantly higher in the MELD >/= 10 group 
      (p < 0.001). As a result of Univariate and Multivariate analysis, MELD score was 
      found to be the independent predictors of ICU, in-hospital mortality, intubation, 
      and recurrent hospitalization (p < 0.001). MELD score 18.5 predicted ICU with 99% 
      sensitivity and 100% specificity (area under curve [AUC]: 0.740, 95% confidence 
      interval [CI]: 0.717-0.763, p < 0.001) also MELD score 18.5 predicted 
      in-hospital mortality with 99% sensitivity and 100% specificity (AUC: 0.797, 
      95% CI: 0.775-0.818, p < 0.001). The MELD score was found to be the independent 
      predictors of in-hospital mortality, ICU admission, and intubation in COVID-19 
      patients.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Kaya, Yasemin
AU  - Kaya Y
AUID- ORCID: 0000-0001-7360-8090
AD  - Department of Internal Medicine, Ordu University Medical Faculty, Ordu, Turkey.
FAU - Gulcu, Oktay
AU  - Gulcu O
AD  - Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
FAU - Aksakal, Emrah
AU  - Aksakal E
AD  - Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
FAU - Kalkan, Kamuran
AU  - Kalkan K
AD  - Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
FAU - Aydin, Sidar S
AU  - Aydin SS
AD  - Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
FAU - Kaya, Ahmet
AU  - Kaya A
AD  - Department of Cardiology, Ordu University Medical Faculty, Ordu, Turkey.
FAU - Bostan, Sedat
AU  - Bostan S
AD  - Health Care Management Department, Faculty of Health Science, Karadeniz 
      Techinical University, Trabzon, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220910
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
SB  - IM
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - *End Stage Liver Disease/diagnosis
MH  - Severity of Illness Index
MH  - Retrospective Studies
MH  - Prognosis
MH  - *COVID-19/diagnosis/complications
MH  - Hospitals
PMC - PMC9539042
OTO - NOTNLM
OT  - COVID-19
OT  - in-hospital mortality
OT  - intensive care unit admission
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/01 06:00
MHDA- 2023/01/11 06:00
PMCR- 2022/09/10
CRDT- 2022/08/31 03:44
PHST- 2022/08/13 00:00 [revised]
PHST- 2022/06/26 00:00 [received]
PHST- 2022/08/27 00:00 [accepted]
PHST- 2022/09/01 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/08/31 03:44 [entrez]
PHST- 2022/09/10 00:00 [pmc-release]
AID - JMV28109 [pii]
AID - 10.1002/jmv.28109 [doi]
PST - ppublish
SO  - J Med Virol. 2023 Jan;95(1):e28109. doi: 10.1002/jmv.28109. Epub 2022 Sep 10.