PMID- 36043439
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231120
IS  - 1445-5994 (Electronic)
IS  - 1444-0903 (Linking)
VI  - 53
IP  - 10
DP  - 2023 Oct
TI  - Retrospective cohort study of hypersomnias of central origin from two Australian 
      tertiary sleep disorders services.
PG  - 1783-1789
LID - 10.1111/imj.15920 [doi]
AB  - BACKGROUND: Hypersomnias of central origin (HOCO) are diverse in origin and 
      symptomatology and remain poorly described in an Australian population. We 
      hypothesised that the rate of human leukocyte antigen (HLA) DQB1*0602 positivity 
      in the Australian cohort would be comparable to international registries. AIMS: 
      The current study aims to evaluate epidemiological and clinical characteristics 
      of Australian patients with HOCO, including prevalence of HLA DQB1*0602 
      positivity, the most specific HLA marker associated with narcolepsy. METHODS: 
      This is a retrospective study. Patients >/= 16 years of age presenting with 
      symptoms of hypersomnolence who attended one of two Australian sleep centres (New 
      South Wales and Queensland) in the preceding 24 months and had undergone both HLA 
      serology and multiple sleep latency tests (MSLTs) were included. Main outcome 
      measures included demographics, HLA DQB1*0602 positivity, MSLT, and clinical 
      parameters (presence of auxiliary narcolepsy symptoms, laboratory tests, relevant 
      prescribed medications). RESULTS: Eighty-eight patients were included. HLA 
      DQB1*0602 positivity was highest in those with type 1 narcolepsy (NT1) (95.7%) 
      and lowest in those without a classifiable disorder (9.1%). Mean sleep latency 
      was lowest and number of sleep-onset rapid eye movement periods (SOREMPs) highest 
      in the NT1 group. Comorbid disorders, particularly depression and 
      overweight/obesity, were prevalent in all cohorts. Across all diagnostic groups, 
      dexamphetamine was the most commonly prescribed agent for excessive daytime 
      sleepiness. CONCLUSIONS: Patients with HOCO assessed in two specialised 
      Australian clinics demonstrate comparable clinical characteristics to other 
      published cohorts internationally; however, available pharmacological agents in 
      Australia do not reflect international standards of care.
CI  - (c) 2022 The Authors. Internal Medicine Journal published by John Wiley & Sons 
      Australia, Ltd on behalf of Royal Australasian College of Physicians.
FAU - Stranks, Lachlan
AU  - Stranks L
AUID- ORCID: 0000-0002-8337-2357
AD  - Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
AD  - Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, 
      Sydney, New South Wales, Australia.
AD  - Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 
      Australia.
FAU - Ellender, Claire M
AU  - Ellender CM
AD  - Princess Alexandra Hospital, Brisbane, Queensland, Australia.
FAU - Wong, Keith
AU  - Wong K
AD  - Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
AD  - Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, 
      Sydney, New South Wales, Australia.
AD  - Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 
      Australia.
FAU - Naqvi, Haider
AU  - Naqvi H
AD  - Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
FAU - Grunstein, Ron
AU  - Grunstein R
AD  - Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
AD  - Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 
      Australia.
FAU - Yee, Brendon J
AU  - Yee BJ
AD  - Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
AD  - Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, 
      Sydney, New South Wales, Australia.
AD  - Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 
      Australia.
FAU - Sivam, Sheila
AU  - Sivam S
AD  - Woolcock Institute of Medical Research, Sydney, New South Wales, Australia.
AD  - Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, 
      Sydney, New South Wales, Australia.
AD  - Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20220917
PL  - Australia
TA  - Intern Med J
JT  - Internal medicine journal
JID - 101092952
SB  - IM
MH  - Humans
MH  - Infant
MH  - Retrospective Studies
MH  - Australia/epidemiology
MH  - *Disorders of Excessive Somnolence/diagnosis
MH  - *Narcolepsy/diagnosis/epidemiology
MH  - Sleep
OTO - NOTNLM
OT  - HLA antigens
OT  - demographics
OT  - disorders of excessive somnolence
OT  - idiopathic hypersomnia
OT  - narcolepsy
EDAT- 2022/09/01 06:00
MHDA- 2023/10/23 12:42
CRDT- 2022/08/31 05:33
PHST- 2022/05/19 00:00 [received]
PHST- 2022/08/25 00:00 [accepted]
PHST- 2023/10/23 12:42 [medline]
PHST- 2022/09/01 06:00 [pubmed]
PHST- 2022/08/31 05:33 [entrez]
AID - 10.1111/imj.15920 [doi]
PST - ppublish
SO  - Intern Med J. 2023 Oct;53(10):1783-1789. doi: 10.1111/imj.15920. Epub 2022 Sep 
      17.