PMID- 36044841
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221018
IS  - 2211-1247 (Electronic)
VI  - 40
IP  - 9
DP  - 2022 Aug 30
TI  - Identification of Lsd1-interacting non-coding RNAs as regulators of fly 
      oogenesis.
PG  - 111294
LID - S2211-1247(22)01114-7 [pii]
LID - 10.1016/j.celrep.2022.111294 [doi]
AB  - Lysine-specific demethylase 1 (Lsd1) plays a key role in balancing cell 
      proliferation and differentiation. Lsd1 has been recently reported to associate 
      with specific long noncoding RNAs (lncRNAs) to account for oncogenic gene 
      expression in cancer cells. However, how lncRNA-Lsd1 interplay affects 
      cell-specific differentiation remains elusive in vivo. Here, through Lsd1 
      specific RNA immunopecipitation sequencing (RIP-seq) experiments, we identify 
      three long hairpin RNAs as Lsd1-interacting non-coding RNAs (LINRs) from fly 
      ovaries. Knocking out LINR-1 and LINR-2 affects fly egg production, while each of 
      the LINR deletion mutant females produce eggs with reduced hatch rate, indicating 
      important functions of LINRs in supporting oogenesis. At the cellular level, 
      LINR-2 regulates the differentiation of germline stem cells and follicle 
      progenitors likely though modulating the expression and function of Lsd1 in vivo. 
      Our identification of ovarian LINRs presents a physiological example of dynamic 
      lncRNA-Lsd1 interplay that regulates stem cell/progenitor differentiation.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Shao, Tzu-Ling
AU  - Shao TL
AD  - Department of Life Sciences and Institute of Genome Sciences, National Yang Ming 
      Chiao Tung University, Taipei, Taiwan.
FAU - Ting, Ruei-Teng
AU  - Ting RT
AD  - Department of Life Sciences and Institute of Genome Sciences, National Yang Ming 
      Chiao Tung University, Taipei, Taiwan.
FAU - Lee, Ming-Chia
AU  - Lee MC
AD  - Department of Life Sciences and Institute of Genome Sciences, National Yang Ming 
      Chiao Tung University, Taipei, Taiwan. Electronic address: 
      lee.mingchia@nycu.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
RN  - 0 (RNA, Long Noncoding)
RN  - EC 1.14.11.- (Histone Demethylases)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/genetics
MH  - Cell Proliferation
MH  - Female
MH  - *Histone Demethylases/genetics
MH  - Oogenesis/genetics
MH  - *RNA, Long Noncoding/genetics
OTO - NOTNLM
OT  - CP: Developmental biology
OT  - CP: Molecular biology
OT  - Lsd1
OT  - Lsd1-interacting noncoding RNA
OT  - fly oogenesis
OT  - follicle progenitors
OT  - germline stem cells
OT  - long hairpin RNAs
OT  - lysine-specific demethylase 1
COIS- Declaration of interests The authors declare that we have no conflict of 
      interest.
EDAT- 2022/09/01 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/08/31 18:23
PHST- 2022/01/14 00:00 [received]
PHST- 2022/06/03 00:00 [revised]
PHST- 2022/08/10 00:00 [accepted]
PHST- 2022/08/31 18:23 [entrez]
PHST- 2022/09/01 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
AID - S2211-1247(22)01114-7 [pii]
AID - 10.1016/j.celrep.2022.111294 [doi]
PST - ppublish
SO  - Cell Rep. 2022 Aug 30;40(9):111294. doi: 10.1016/j.celrep.2022.111294.