PMID- 36045057
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221227
IS  - 2234-3814 (Electronic)
IS  - 2234-3806 (Print)
IS  - 2234-3806 (Linking)
VI  - 43
IP  - 1
DP  - 2023 Jan 1
TI  - Indirect Method for Estimation of Reference Intervals of Inflammatory Markers.
PG  - 55-63
LID - 10.3343/alm.2023.43.1.55 [doi]
AB  - BACKGROUND: The direct method for reference interval (RI) estimating is limited 
      due to the requirement of resources, difficulties in defining a non-diseased 
      population, or ethical problems in obtaining samples. We estimated the RI for 
      inflammatory biomarkers using an indirect method (RII). METHODS: C-reactive 
      protein (CRP), erythrocyte sedimentation rate (ESR) and presepsin (PSEP) data of 
      patients visiting a single hospital were retrieved from April 2009 to April 2021. 
      Right-skewed data were transformed using the Box-Cox transformation method. A 
      mixed population of non-diseased and diseased distributions was assumed, followed 
      by latent profile analysis for the two classes. The intersection point of the 
      distribution curve was estimated as the RI. The influence of measurement size was 
      evaluated as the ratio of abnormal values and adjustment (nxbandwidth) of the 
      distribution curve. RESULTS: The RIs estimated by the proposed RII method 
      (existing method) were as follows: CRP, 0-4.1 (0-4.7) mg/L; ESR, 0-10.2 (0-15) 
      mm/hr and PSEP, 0-411 (0-300) pg/mL. Measurement sizes >/=2,500 showed stable 
      results. An abnormal-to-normal value ratio of 0.5 showed the most accurate result 
      for CRP. Adjustment values </=5 or >5 were applicable for a measurement size 
      <25,000 or >/=25,000, respectively. CONCLUSIONS: The proposed RII method could 
      provide additional information for RI verification or estimation with some 
      limitations.
FAU - Kang, Taewon
AU  - Kang T
AUID- ORCID: 0000-0002-0452-3322
AD  - Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Yoo, Jeaeun
AU  - Yoo J
AUID- ORCID: 0000-0001-9917-5393
AD  - Department of Laboratory Medicine, Incheon St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Jekarl, Dong Wook
AU  - Jekarl DW
AUID- ORCID: 0000-0002-6269-5501
AD  - Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
AD  - Research and Development Institute for In Vitro Diagnostic Medical Devices, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Chae, Hyojin
AU  - Chae H
AUID- ORCID: 0000-0001-5870-1887
AD  - Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Myungshin
AU  - Kim M
AUID- ORCID: 0000-0001-8632-0168
AD  - Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Park, Yeon-Joon
AU  - Park YJ
AUID- ORCID: 0000-0003-2182-5821
AD  - Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Oh, Eun-Jee
AU  - Oh EJ
AUID- ORCID: 0000-0001-5870-915X
AD  - Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
AD  - Research and Development Institute for In Vitro Diagnostic Medical Devices, 
      College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kim, Yonggoo
AU  - Kim Y
AUID- ORCID: 0000-0003-2808-3795
AD  - Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of 
      Medicine, The Catholic University of Korea, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20220901
PL  - Korea (South)
TA  - Ann Lab Med
JT  - Annals of laboratory medicine
JID - 101571172
RN  - 0 (Biomarkers)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Peptide Fragments)
RN  - 0 (presepsin protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Biomarkers
MH  - Blood Sedimentation
MH  - *C-Reactive Protein
MH  - Humans
MH  - Lipopolysaccharide Receptors
MH  - *Peptide Fragments
MH  - Reference Values
PMC - PMC9467833
OTO - NOTNLM
OT  - Latent variable modeling
OT  - Reference range
OT  - Statistical data interpretation
OT  - Statistical distributions
COIS- CONFLICTS OF INTEREST The authors declare no competing interests.
EDAT- 2022/09/01 06:00
MHDA- 2022/09/09 06:00
PMCR- 2022/09/01
CRDT- 2022/08/31 22:32
PHST- 2022/03/11 00:00 [received]
PHST- 2022/05/09 00:00 [revised]
PHST- 2022/08/17 00:00 [accepted]
PHST- 2022/08/31 22:32 [entrez]
PHST- 2022/09/01 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/09/01 00:00 [pmc-release]
AID - alm.2023.43.1.55 [pii]
AID - alm-43-1-55 [pii]
AID - 10.3343/alm.2023.43.1.55 [doi]
PST - ppublish
SO  - Ann Lab Med. 2023 Jan 1;43(1):55-63. doi: 10.3343/alm.2023.43.1.55. Epub 2022 Sep 
      1.