PMID- 36046756
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220907
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 42
DP  - 2022 Oct
TI  - Peripartum cardiomyopathy: Characteristics and outcomes among women seen at a 
      referral hospital in Lusaka, Zambia.
PG  - 101104
LID - 10.1016/j.ijcha.2022.101104 [doi]
LID - 101104
AB  - BACKGROUND: Peripartum cardiomyopathy (PPCM) disproportionately affects women of 
      African descent, however knowledge about this disease in African countries is 
      limited. OBJECTIVES: To describe the phenotype of women with PPCM seen at a 
      referral hospital in Zambia and examine outcomes at 6 months. METHODS: A 
      prospective observational study describing characteristics and 6-month outcomes 
      was performed at the University Teaching Hospital Echocardiography Lab in Lusaka, 
      Zambia. RESULTS: We enrolled 45 participants with PPCM and 38 were seen at 
      6-month follow up; 3 (7 %) died and 4 (9 %) were lost to follow up. Mean age was 
      32.9 years (SD:7.0); mean BMI was 25.3 kg/m(2) (SD:4.1), mean parity was 3.4 
      (SD:2.2) children and twin pregnancies occurred in 4 (9 %). Median time from 
      symptom onset to diagnosis was 60 days (IQR: 1-280). 20 (44 %) reported 
      gestational hypertension and 10 (22 %) reported preeclampsia. Baseline median 
      left ventricular ejection fraction (LVEF) was 36 % (IQR: 11-45), median left 
      ventricular end-diastolic volume (LVEDV) was 150 mL (IQR: 58-229) and 79 % 
      described New York Heart Association (NYHA) functional class IV symptoms. Median 
      LVEF after 6 months was 49 % (IQR: 23-68; p < 0.001) and median LVEDV was 121 mL 
      (IQR: 66-200; p < 0.001). At 6-month follow up 45 % had LVEF >/= 50 %, 42 % had 
      LVEDV </= 106 mL and 1 (3 %) had NYHA functional class IV symptoms. CONCLUSIONS: 
      Hypertension was prevalent in this cohort. Overall mortality rate was low and 
      clinically significant improvements in cardiac parameters were seen in over 40%. 
      Further research is needed to identify and mitigate gaps in diagnosis and 
      management.
CI  - (c) 2022 The Author(s).
FAU - Strasserking, Fiona E
AU  - Strasserking FE
AD  - Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt 
      University Medical Center, Nashville, TN, USA.
AD  - Division of Cardiovascular Medicine and Office of Global Health, University of 
      Texas Southwestern Medical Center, Dallas, TX, USA.
FAU - Musho, Jane
AU  - Musho J
AD  - University Teaching Hospital, Lusaka, Zambia.
FAU - Heimburger, Douglas C
AU  - Heimburger DC
AD  - Vanderbilt Institute for Global Health and Division of Epidemiology, Department 
      of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
FAU - Mutale, Wilbroad
AU  - Mutale W
AD  - University of Zambia School of Public Health, Lusaka, Zambia.
FAU - Damp, Julie A
AU  - Damp JA
AD  - Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt 
      University Medical Center, Nashville, TN, USA.
FAU - Mumba, Ngosa
AU  - Mumba N
AD  - University Teaching Hospital, Lusaka, Zambia.
FAU - Goma, Fastone
AU  - Goma F
AD  - University of Zambia School of Medicine, Lusaka, Zambia.
LA  - eng
PT  - Journal Article
DEP - 20220822
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC9421395
OTO - NOTNLM
OT  - Africa
OT  - Global health
OT  - Heart failure
OT  - Peripartum cardiomyopathy
OT  - Zambia
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/09/02 06:00
MHDA- 2022/09/02 06:01
PMCR- 2022/08/22
CRDT- 2022/09/01 02:35
PHST- 2022/05/17 00:00 [received]
PHST- 2022/07/21 00:00 [revised]
PHST- 2022/08/07 00:00 [accepted]
PHST- 2022/09/01 02:35 [entrez]
PHST- 2022/09/02 06:00 [pubmed]
PHST- 2022/09/02 06:01 [medline]
PHST- 2022/08/22 00:00 [pmc-release]
AID - S2352-9067(22)00153-1 [pii]
AID - 101104 [pii]
AID - 10.1016/j.ijcha.2022.101104 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2022 Aug 22;42:101104. doi: 
      10.1016/j.ijcha.2022.101104. eCollection 2022 Oct.