PMID- 36046814
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220907
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 13
DP  - 2022
TI  - Astragalus mongholicus powder, a traditional Chinese medicine formula ameliorate 
      type 2 diabetes by regulating adipoinsular axis in diabetic mice.
PG  - 973927
LID - 10.3389/fphar.2022.973927 [doi]
LID - 973927
AB  - The global morbidity of obesity and type 2 diabetes mellitus (T2DM) has 
      dramatically increased. Insulin resistance is the most important pathogenesis and 
      therapeutic target of T2DM. The traditional Chinese medicine formula Astragalus 
      mongholicus powder (APF), consists of Astragalus mongholicus Bunge [Fabaceae], 
      Pueraria montana (Lour.) Merr. [Fabaceae], and Morus alba L. [Moraceae] has a 
      long history to be used to treat diabetes in ancient China. This work aims to 
      investigate the effects of APF on diabetic mice and its underlying mechanism. 
      Diabetic mice were induced by High-fat-diet (HFD) and streptozotocin (STZ). The 
      body weight of mice and their plasma levels of glucose, insulin, leptin and 
      lipids were examined. Reverse transcription-polymerase chain reaction, histology, 
      and Western blot analysis were performed to validate the effects of APF on 
      diabetic mice and investigate the underlying mechanism. APF reduced 
      hyperglycemia, hyperinsulinemia, and hyerleptinemia and attenuate the progression 
      of obesity and non-alcoholic fatty liver disease (NAFLD). However, these effects 
      disappeared in leptin deficient ob/ob diabetic mice and STZ-induced insulin 
      deficient type 1 diabetic mice. Destruction of either these hormones would 
      abolish the therapeutic effects of APF. In addition, APF inhibited the protein 
      expression of PTP1B suppressing insulin-leptin sensitivity, the gluconeogenic 
      gene PEPCK, and the adipogenic gene FAS. Therefore, insulin-leptin sensitivity 
      was normalized, and the gluconeogenic and adipogenic genes were suppressed. In 
      conclusion, APF attenuated obesity, NAFLD, and T2DM by regulating the balance of 
      adipoinsular axis in STZ + HFD induced T2DM mice.
CI  - Copyright (c) 2022 Xu, Ye, Li, Dou, Yu, Feng, Wang, Wan and Rong.
FAU - Xu, Siyuan
AU  - Xu S
AD  - Key Laboratory of Glucolipid Metabolic Disorder, Guangdong TCM Key Laboratory for 
      Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated 
      Chinese and Western Medicine, Ministry of Education of China, Institute of 
      Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
FAU - Ye, Bixian
AU  - Ye B
AD  - Department of Nursing, Medical College of Jiaying University, Meizhou, China.
FAU - Li, Jinlei
AU  - Li J
AD  - School of Chinese Meteria Medica, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Dou, Yonghui
AU  - Dou Y
AD  - School of Chinese Meteria Medica, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
FAU - Yu, Yuying
AU  - Yu Y
AD  - Key Laboratory of Glucolipid Metabolic Disorder, Guangdong TCM Key Laboratory for 
      Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated 
      Chinese and Western Medicine, Ministry of Education of China, Institute of 
      Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
FAU - Feng, Yifan
AU  - Feng Y
AD  - Key Laboratory of Glucolipid Metabolic Disorder, Guangdong TCM Key Laboratory for 
      Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated 
      Chinese and Western Medicine, Ministry of Education of China, Institute of 
      Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
FAU - Wang, Lexun
AU  - Wang L
AD  - Key Laboratory of Glucolipid Metabolic Disorder, Guangdong TCM Key Laboratory for 
      Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated 
      Chinese and Western Medicine, Ministry of Education of China, Institute of 
      Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
FAU - Wan, David Chi-Cheong
AU  - Wan DC
AD  - School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, 
      China.
FAU - Rong, Xianglu
AU  - Rong X
AD  - Key Laboratory of Glucolipid Metabolic Disorder, Guangdong TCM Key Laboratory for 
      Metabolic Diseases, Guangdong Metabolic Diseases Research Center of Integrated 
      Chinese and Western Medicine, Ministry of Education of China, Institute of 
      Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220815
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC9420938
OTO - NOTNLM
OT  - Astragalus mongholicus powder
OT  - adipoinsular axis
OT  - insulin resistance
OT  - leptin
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/02 06:00
MHDA- 2022/09/02 06:01
PMCR- 2022/08/15
CRDT- 2022/09/01 02:36
PHST- 2022/06/20 00:00 [received]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/09/01 02:36 [entrez]
PHST- 2022/09/02 06:00 [pubmed]
PHST- 2022/09/02 06:01 [medline]
PHST- 2022/08/15 00:00 [pmc-release]
AID - 973927 [pii]
AID - 10.3389/fphar.2022.973927 [doi]
PST - epublish
SO  - Front Pharmacol. 2022 Aug 15;13:973927. doi: 10.3389/fphar.2022.973927. 
      eCollection 2022.