PMID- 36046986
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221130
IS  - 1108-7161 (Print)
IS  - 1108-7161 (Linking)
VI  - 22
IP  - 3
DP  - 2022 Sep 1
TI  - No evidence of mineralization abnormalities in iliac bone of premenopausal women 
      with type 2 diabetes mellitus.
PG  - 305-315
AB  - OBJECTIVES: Patients with type-2 diabetes mellitus (T2DM) have increased risk for 
      bone fractures which points towards impaired bone quality. METHODS: We measured 
      bone mineralization density distribution (BMDD) and osteocyte lacunae section 
      (OLS) characteristics based on quantitative backscattered electron images of 
      transiliac biopsy samples from n=26 premenopausal women with T2DM. Outcomes were 
      compared to those from reference cohorts as well as between T2DM subgroups 
      defined by clinical characteristics. RESULTS: Comparison to references did not 
      reveal any differences in BMDD (all p>0.05) but a lowered OLS-density in 
      cancellous bone in T2DM (-14.9%, p<0.001). Neither BMDD nor OLS-characteristics 
      differed in T2DM subgroups defined by HbA1c (<7% versus >7%). The average degree 
      of bone mineralization (CaMean) was higher (0.44 wt%Ca in T2DM, 0.30 wt%Ca in 
      reference) and consistently the calcium concentration between the tetracycline 
      double labels (CaYoung) was higher (0.76 wt%Ca, all p<0.001) in cancellous versus 
      cortical bone. CONCLUSIONS: Our findings suggest that bone matrix mineralization 
      was neither affected by the presence nor by the glycemic control of T2DM in our 
      study cohort. The intra-individual differences between cancellous and cortical 
      bone mineralization gave evidence for differences in the time course of the early 
      mineralization process in these compartments in general.
FAU - Misof, Barbara M
AU  - Misof BM
AD  - Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of OEGK and AUVA, 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, 
      Austria.
FAU - Blouin, Stephane
AU  - Blouin S
AD  - Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of OEGK and AUVA, 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, 
      Austria.
FAU - Andrade, Vicente F C
AU  - Andrade VFC
AD  - Endocrine Division (SEMPR), Hospital de Clinicas, Federal University of Parana, 
      Curitiba, Brazil.
FAU - Roschger, Paul
AU  - Roschger P
AD  - Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of OEGK and AUVA, 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, 
      Austria.
FAU - Borba, Victoria Z C
AU  - Borba VZC
AD  - Endocrine Division (SEMPR), Hospital de Clinicas, Federal University of Parana, 
      Curitiba, Brazil.
FAU - Hartmann, Markus A
AU  - Hartmann MA
AD  - Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of OEGK and AUVA, 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, 
      Austria.
FAU - Zwerina, Jochen
AU  - Zwerina J
AD  - Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of OEGK and AUVA, 
      Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, 
      Austria.
FAU - Recker, Robert R
AU  - Recker RR
AD  - Creighton University Osteoporosis Research Center, Omaha, NE, United States of 
      America.
FAU - Moreira, Carolina A
AU  - Moreira CA
AD  - Endocrine Division (SEMPR), Hospital de Clinicas, Federal University of Parana, 
      Curitiba, Brazil.
AD  - Academic Research Center, Pro Renal Institution Curitiba, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - J Musculoskelet Neuronal Interact
JT  - Journal of musculoskeletal & neuronal interactions
JID - 101084496
SB  - IM
MH  - Bone Density
MH  - Bone and Bones
MH  - Calcification, Physiologic
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Humans
MH  - Premenopause
PMC - PMC9438521
OTO - NOTNLM
OT  - Bone Matrix Mineralization
OT  - Mineralization Processes
OT  - Osteocyte Lacunae
OT  - Transiliac Bone Biopsy
OT  - Type-2 Diabetes Mellitus
COIS- The authors have no conflict of interest.
EDAT- 2022/09/02 06:00
MHDA- 2022/09/09 06:00
PMCR- 2022/01/01
CRDT- 2022/09/01 03:02
PHST- 2022/09/01 03:02 [entrez]
PHST- 2022/09/02 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - JMNI-22-305 [pii]
PST - ppublish
SO  - J Musculoskelet Neuronal Interact. 2022 Sep 1;22(3):305-315.