PMID- 36047065
OWN - NLM
STAT- MEDLINE
DCOM- 20230508
LR  - 20230515
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 129
IP  - 11
DP  - 2023 Jun 14
TI  - Effect of taurine on glycaemic, lipid and inflammatory profile in individuals 
      with type 2 diabetes: study protocol of a randomised trial.
PG  - 1871-1876
LID - 10.1017/S0007114522002768 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is characterised by chronic hyperglycaemia. 
      Despite the efficacy of conventional pharmacotherapy, some individuals do not 
      reach glycaemic goals and require adjuvant therapies. Taurine, a semi-essential 
      amino acid, decreases blood glucose and cholesterol levels in rodents and humans. 
      However, glycated hemoglobin (HbA1c) has not been evaluated in randomised 
      controlled trials after taurine treatment for more than 12 weeks. This study aims 
      to evaluate the effect of taurine administration on glycaemic, lipid, 
      inflammatory, anthropometric and dietary parameters in individuals with T2DM. A 
      randomised, double-blind, placebo-controlled clinical trial will be conducted at 
      the Clinical Research Center of a tertiary public hospital. Participants with 
      T2DM (n 94) will be recruited and randomised to receive 3 g of taurine or 
      placebo, twice/day, orally, for 12 weeks. Blood samples will be collected before 
      and after 12 weeks of treatment, when HbA1c, fasting glucose, insulin, 
      albuminuria, creatinine, total cholesterol and fractions, triglycerides, 
      C-reactive protein, TNF-alpha, IL 1, 4, 5, 6, 10 and 13 will be evaluated. 
      Anthropometric parameters and 24-hour food recall will also be evaluated. The 
      study will evaluate the effect of taurine treatment on biochemical and 
      anthropometric parameters in individuals with T2DM. These results will guide the 
      decision-making to indicate taurine treatment as an adjunct in individuals with 
      T2DM who have not reached their glycaemic goal.
FAU - Caletti, Greice
AU  - Caletti G
AD  - Universidade Federal do Rio Grande do Sul, Medical School, Porto Alegre, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Endocrine Division, Porto Alegre, Brazil.
FAU - Cardoso, Monique Vargas
AU  - Cardoso MV
AD  - Faculdades Integradas de Taquara, Taquara, Brazil.
FAU - Scheffel, Rafael Selbach
AU  - Scheffel RS
AD  - Universidade Federal do Rio Grande do Sul, Medical School, Porto Alegre, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Endocrine Division, Porto Alegre, Brazil.
AD  - Universidade Federal do Rio Grande do Sul, Departament of Pharmacology, Instituto 
      de Ciencias Basicas da Saude, Porto Alegre, Brazil.
FAU - Schaan, Beatriz D
AU  - Schaan BD
AD  - Universidade Federal do Rio Grande do Sul, Medical School, Porto Alegre, Brazil.
AD  - Hospital de Clinicas de Porto Alegre, Endocrine Division, Porto Alegre, Brazil.
FAU - Gomez, Rosane
AU  - Gomez R
AD  - Universidade Federal do Rio Grande do Sul, Departament of Pharmacology, Instituto 
      de Ciencias Basicas da Saude, Porto Alegre, Brazil.
FAU - Bock, Patricia Martins
AU  - Bock PM
AUID- ORCID: 0000-0001-8572-3950
AD  - Universidade Federal do Rio Grande do Sul, Departament of Pharmacology, Instituto 
      de Ciencias Basicas da Saude, Porto Alegre, Brazil.
AD  - Faculdades Integradas de Taquara, Taquara, Brazil.
LA  - eng
PT  - Clinical Trial Protocol
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220901
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Glycated Hemoglobin
MH  - Blood Glucose/metabolism
MH  - Double-Blind Method
MH  - Lipids
MH  - Cholesterol
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - Cholesterol
OT  - Cytokines
OT  - Diabetes mellitus
OT  - Glycated hemoglobin
OT  - Hyperglycaemia
OT  - Taurine
EDAT- 2022/09/02 06:00
MHDA- 2023/05/08 10:17
CRDT- 2022/09/01 03:33
PHST- 2023/05/08 10:17 [medline]
PHST- 2022/09/02 06:00 [pubmed]
PHST- 2022/09/01 03:33 [entrez]
AID - S0007114522002768 [pii]
AID - 10.1017/S0007114522002768 [doi]
PST - ppublish
SO  - Br J Nutr. 2023 Jun 14;129(11):1871-1876. doi: 10.1017/S0007114522002768. Epub 
      2022 Sep 1.