PMID- 36051027
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220907
IS  - 2688-6146 (Electronic)
IS  - 2688-6146 (Linking)
VI  - 3
IP  - 3
DP  - 2022 Aug
TI  - Inactivating BTK mutations in large B-cell lymphoma in a real-world cohort: 
      Strong correlation with BCL2 translocation.
PG  - 936-939
LID - 10.1002/jha2.489 [doi]
AB  - Inactivating mutations in Bruton's tyrosine kinase (BTK) in patients with 
      follicular lymphoma (FL) have recently been reported. These mutations were found 
      in BTK inhibitor-treatment naive patients. Here, we report the BTK mutation 
      status in a real-world cohort of patients with non-Hodgkin lymphoma. We found 
      primary BTK mutations in 7.7% of patients with large B-cell lymphoma (LBCL) and 
      in 14.1% of patients with FL. All patients with BTK-mutated LBCL were BCL2 
      translocation positive, and the correlation between BCL2 translocation and BTK 
      mutation persisted even when patients with known transformation from FL were 
      excluded.
CI  - (c) 2022 The Authors. eJHaem published by British Society for Haematology and John 
      Wiley & Sons Ltd.
FAU - Schejbel, Lone
AU  - Schejbel L
AUID- ORCID: 0000-0003-3677-3227
AD  - Department of Pathology Copenhagen University Hospital Herlev Denmark.
FAU - Breinholt, Marie Fredslund
AU  - Breinholt MF
AD  - Department of Pathology Copenhagen University Hospital Rigshospitalet Denmark.
FAU - Gang, Anne Ortved
AU  - Gang AO
AD  - Department of Haematology Copenhagen University Hospital Rigshospitalet Denmark.
FAU - Nielsen, Torsten Holm
AU  - Nielsen TH
AD  - Department of Haematology Copenhagen University Hospital Rigshospitalet Denmark.
FAU - Pedersen, Lars Moller
AU  - Pedersen LM
AD  - Department of Haematology Zealand University Hospital Roskilde Denmark.
FAU - Hogdall, Estrid
AU  - Hogdall E
AD  - Department of Pathology Copenhagen University Hospital Herlev Denmark.
FAU - Norgaard, Peter
AU  - Norgaard P
AD  - Department of Pathology Copenhagen University Hospital Herlev Denmark.
LA  - eng
PT  - Journal Article
DEP - 20220624
PL  - United States
TA  - EJHaem
JT  - EJHaem
JID - 101761942
PMC - PMC9421985
OTO - NOTNLM
OT  - BTK
OT  - molecular pathology
OT  - non-Hodgkin lymphoma
COIS- The authors declare they have no conflicts of interest.
EDAT- 2022/09/03 06:00
MHDA- 2022/09/03 06:01
PMCR- 2022/06/24
CRDT- 2022/09/02 02:24
PHST- 2022/04/29 00:00 [received]
PHST- 2022/05/16 00:00 [revised]
PHST- 2022/05/17 00:00 [accepted]
PHST- 2022/09/02 02:24 [entrez]
PHST- 2022/09/03 06:00 [pubmed]
PHST- 2022/09/03 06:01 [medline]
PHST- 2022/06/24 00:00 [pmc-release]
AID - JHA2489 [pii]
AID - 10.1002/jha2.489 [doi]
PST - epublish
SO  - EJHaem. 2022 Jun 24;3(3):936-939. doi: 10.1002/jha2.489. eCollection 2022 Aug.