PMID- 36051350
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220907
IS  - 2045-8932 (Print)
IS  - 2045-8940 (Electronic)
IS  - 2045-8932 (Linking)
VI  - 12
IP  - 3
DP  - 2022 Jul
TI  - Comparison between thermodilution and Fick methods for resting and 
      exercise-induced cardiac output measurement in patients with chronic dyspnea.
PG  - e12128
LID - 10.1002/pul2.12128 [doi]
LID - e12128
AB  - Studies comparing thermodilution (TD) and the direct Fick method (dFM) for 
      cardiac output (CO) measurement are rare. We compared CO measurements between TD 
      (2-5 cold water injections), the dFM, and indirect Fick method (iFM) at rest and 
      during exercise, and assessed the effect of averaging different numbers of TD 
      measurements during exercise. This retrospective study included 300 patients 
      (52.3% women, mean age 66 +/- 11 years) having pulmonary hypertension (76.0%) or 
      unexplained dyspnea. Invasive hemodynamic and gas exchange parameters were 
      measured at rest (supine; n = 300) and during unloaded cycling (semi-supine; 
      n = 275) and 25-W exercise (semi-supine; n = 240). All three methods showed 
      significant differences in CO measurement (DeltaCO) at rest (p </= 0.001; 
      DeltaCO > 1 L/min: 45.0% [iFM vs. dFM], 42.0% [iFM vs. TD], and 45.7% [TD vs. dFM]). 
      DeltaCO (TD vs. dFM) was significant during unloaded cycling (p < 0.001; 
      DeltaCO > 1 L/min: 56.6%) but not during 25-W exercise (p = 0.137; DeltaCO > 1 L/min: 
      52.8%). DeltaCO (TD vs. dFM) during 25-W exercise was significant when using one or 
      two (p </= 0.01) but not three (p = 0.06) TD measurements. Mean DeltaCO (TD [>/=3 
      measurements] vs. dFM) was -0.43 +/- 1.98 and -0.06 +/- 2.29 L/min during unloaded 
      and 25-W exercise, respectively. Thus, TD and dFM CO measurements are comparable 
      during 25-W exercise (averaging >/=3 TD measurements), but not during unloaded 
      cycling or at rest. Individual DeltaCOs vary substantially and require critical 
      interpretation to avoid CO misclassification.
CI  - (c) 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on 
      behalf of Pulmonary Vascular Research Institute.
FAU - Desole, Susanna
AU  - Desole S
AD  - Division of Pneumology, Department of Internal Medicine B University Hospital 
      Greifswald Greifswald Germany.
FAU - Obst, Anne
AU  - Obst A
AD  - Division of Pneumology, Department of Internal Medicine B University Hospital 
      Greifswald Greifswald Germany.
FAU - Habedank, Dirk
AU  - Habedank D
AD  - Division of Pneumology, Department of Internal Medicine B University Hospital 
      Greifswald Greifswald Germany.
AD  - Division of Cardiology, Department of Internal Medicine DRK-Hospital Berlin 
      Germany.
FAU - Opitz, Christian F
AU  - Opitz CF
AD  - Division of Cardiology, Department of Internal Medicine DRK-Hospital Berlin 
      Germany.
FAU - Knaack, Christine
AU  - Knaack C
AD  - Division of Pneumology, Department of Internal Medicine B University Hospital 
      Greifswald Greifswald Germany.
FAU - Hortien, Franziska
AU  - Hortien F
AD  - Division of Pneumology, Department of Internal Medicine B University Hospital 
      Greifswald Greifswald Germany.
FAU - Heine, Alexander
AU  - Heine A
AD  - Division of Pneumology, Department of Internal Medicine B University Hospital 
      Greifswald Greifswald Germany.
FAU - Stubbe, Beate
AU  - Stubbe B
AUID- ORCID: 0000-0002-7571-744X
AD  - Division of Pneumology, Department of Internal Medicine B University Hospital 
      Greifswald Greifswald Germany.
FAU - Ewert, Ralf
AU  - Ewert R
AD  - Division of Pneumology, Department of Internal Medicine B University Hospital 
      Greifswald Greifswald Germany.
LA  - eng
PT  - Journal Article
DEP - 20220701
PL  - United States
TA  - Pulm Circ
JT  - Pulmonary circulation
JID - 101557243
PMC - PMC9425001
OTO - NOTNLM
OT  - Fick method
OT  - cardiac output
OT  - dyspnea
OT  - exercise
OT  - thermodilution
COIS- RE: Honoraria for scientific lectures from Actelion, GSK, United Therapeutics, 
      AstraZeneca, Novartis, Berlin Chemie, Boehringer Ingelheim, and OMT, and research 
      funding from Boehringer Ingelheim and Actelion Germany. SD, AO, DH, CFO, CK, FH, 
      AH, BS: No potential conflict of interest to report.
EDAT- 2022/09/03 06:00
MHDA- 2022/09/03 06:01
PMCR- 2022/07/01
CRDT- 2022/09/02 02:29
PHST- 2021/07/07 00:00 [received]
PHST- 2022/06/07 00:00 [revised]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2022/09/02 02:29 [entrez]
PHST- 2022/09/03 06:00 [pubmed]
PHST- 2022/09/03 06:01 [medline]
PHST- 2022/07/01 00:00 [pmc-release]
AID - PUL212128 [pii]
AID - 10.1002/pul2.12128 [doi]
PST - epublish
SO  - Pulm Circ. 2022 Jul 1;12(3):e12128. doi: 10.1002/pul2.12128. eCollection 2022 
      Jul.