PMID- 36054647
OWN - NLM
STAT- MEDLINE
DCOM- 20221229
LR  - 20230117
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 24
IP  - 12
DP  - 2022 Dec
TI  - Effects of remote haemodynamic-guided heart failure management in patients with 
      different subtypes of pulmonary hypertension: insights from the MEMS-HF study.
PG  - 2320-2330
LID - 10.1002/ejhf.2656 [doi]
AB  - AIM: The CardioMEMS European Monitoring Study for Heart Failure (MEMS-HF) 
      investigated safety and efficacy of pulmonary artery pressure (PAP)-guided remote 
      patient management (RPM) in New York Heart Association (NYHA) class III 
      outpatients with at least one heart failure hospitalization (HFH) during the 
      previous 12 months. This pre-specified subgroup analysis investigated whether RPM 
      effects depended on presence and subtype of pulmonary hypertension (PH). METHODS 
      AND RESULTS: In 106/234 MEMS-HF participants, Swan-Ganz catheter tracings 
      obtained during sensor implant were available for off-line manual analysis 
      jointly performed by two experts. Patients were classified into subgroups 
      according to current PH definitions. Isolated post-capillary PH (IpcPH) and 
      combined post- and pre-capillary PH (CpcPH) were present in 38 and 36 patients, 
      respectively, whereas 31 patients had no PH. Clinical characteristics were 
      comparable between subgroups, but among patients with PH pulmonary vascular 
      resistance was higher (p = 0.029) and pulmonary artery compliance lower 
      (p = 0.003) in patients with CpcPH. During 12 months of PAP-guided RPM, all PAPs 
      declined in IpcPH and CpcPH subgroups (all p < 0.05), whereas only mean and 
      diastolic PAP decreased in patients without PH (both p < 0.05). Improvements in 
      post- versus pre-implant HFH rates were similar in CpcPH (0.639 
      events/patient-year; hazard ratio [HR] 0.37) and IpcPH (0.72 events/patient-year; 
      HR 0.45) patients. Participants without PH benefited most (0.26 
      events/patient-year; HR 0.17, p = 0.04 vs. IpcPH/CpcPH patients). Quality of life 
      and NYHA class improved significantly in all subgroups. CONCLUSIONS: Outpatients 
      with NYHA class III symptoms with at least one HFH during 1 year pre-implant 
      benefitted significantly from PAP-guided RPM during post-implant follow-up 
      irrespective of presence or subtype of PH at baseline.
CI  - (c) 2022 The Authors. European Journal of Heart Failure published by John Wiley & 
      Sons Ltd on behalf of European Society of Cardiology.
FAU - Assmus, Birgit
AU  - Assmus B
AD  - Cardiology, Department of Medicine, Goethe University Hospital, Frankfurt, 
      Germany.
AD  - Medical Clinic I, Department of Cardiology, University Hospital Giessen, Justus 
      Liebig University Giessen, Giessen, Germany.
FAU - Angermann, Christiane E
AU  - Angermann CE
AD  - Comprehensive Heart Failure Center, University Hospital Wurzburg, Wurzburg, 
      Germany.
FAU - Alkhlout, Basil
AU  - Alkhlout B
AD  - Klinikum Karlsburg, Heart and Diabetes Center Mecklenburg-Western Pommerania, 
      Karlsburg, Germany.
FAU - Asselbergs, Folkert W
AU  - Asselbergs FW
AD  - Division Heart & Lungs, Department of Cardiology, University Medical Centre 
      Utrecht, Utrecht, The Netherlands.
FAU - Schnupp, Steffen
AU  - Schnupp S
AD  - Medical Centre Coburg GmbH II, Medical Clinic Cardiology, Angiology, Pulmonology, 
      Coburg, Germany.
FAU - Brugts, Jasper J
AU  - Brugts JJ
AD  - Thorax Center, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
FAU - Nordbeck, Peter
AU  - Nordbeck P
AD  - Comprehensive Heart Failure Center, University Hospital Wurzburg, Wurzburg, 
      Germany.
AD  - Cardiology, Department of Medicine I, Centre for Internal Medicine, University 
      Hospital Wurzburg, Wurzburg, Germany.
FAU - Zhou, Qian
AU  - Zhou Q
AD  - Department of Cardiology and Angiology I, University Heart Center Freiburg, 
      University of Freiburg, Bad Krozingen, Germany.
FAU - Brett, Marie-Elena
AU  - Brett ME
AD  - Abbott, Sylmar, Sylmar, CA, USA.
FAU - Ginn, Greg
AU  - Ginn G
AD  - Abbott, Sylmar, Sylmar, CA, USA.
FAU - Adamson, Philip B
AU  - Adamson PB
AD  - Abbott, Sylmar, Sylmar, CA, USA.
FAU - Bohm, Michael
AU  - Bohm M
AD  - Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Saarland 
      University, Homburg, Germany.
FAU - Rosenkranz, Stephan
AU  - Rosenkranz S
AD  - Clinic III for Internal Medicine, and Cologne Cardiovascular Research Center 
      (CCRC), University of Cologne Heart Center, Koln, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221103
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
CIN - Eur J Heart Fail. 2022 Dec;24(12):2331-2332. PMID: 36164934
MH  - Humans
MH  - *Hypertension, Pulmonary/therapy
MH  - *Heart Failure/diagnosis
MH  - Quality of Life
MH  - *Micro-Electrical-Mechanical Systems
MH  - Hemodynamics
OTO - NOTNLM
OT  - Heart failure
OT  - Hospitalization
OT  - Pulmonary artery pressure
OT  - Pulmonary hypertension
OT  - Remote monitoring
EDAT- 2022/09/03 06:00
MHDA- 2022/12/30 06:00
CRDT- 2022/09/02 14:45
PHST- 2022/07/17 00:00 [revised]
PHST- 2021/10/10 00:00 [received]
PHST- 2022/08/10 00:00 [accepted]
PHST- 2022/09/03 06:00 [pubmed]
PHST- 2022/12/30 06:00 [medline]
PHST- 2022/09/02 14:45 [entrez]
AID - 10.1002/ejhf.2656 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2022 Dec;24(12):2320-2330. doi: 10.1002/ejhf.2656. Epub 2022 
      Nov 3.