PMID- 36056919
OWN - NLM
STAT- MEDLINE
DCOM- 20221226
LR  - 20230629
IS  - 2156-5376 (Electronic)
IS  - 2161-8313 (Print)
IS  - 2161-8313 (Linking)
VI  - 13
IP  - 6
DP  - 2022 Dec 22
TI  - Saturated Fatty Acid Intake and Risk of Type 2 Diabetes: An Updated Systematic 
      Review and Dose-Response Meta-Analysis of Cohort Studies.
PG  - 2125-2135
LID - 10.1093/advances/nmac071 [doi]
AB  - This systematic review and meta-analysis was conducted to pool findings of cohort 
      studies that investigated hazards of type 2 diabetes mellitus (T2DM) in relation 
      to intakes of SFAs. A systematic search was conducted in the PubMed, Scopus, and 
      Embase databases up to June 2021 to find eligible studies. Review articles or 
      commentaries, clinical trials, cross-sectional studies, studies on gestational or 
      type 1 diabetes patients, animal studies, articles with no access to full-texts, 
      articles published in non-English languages, and articles with missing critical 
      data needed for the systematic review were excluded from the meta-analysis. A 
      random-effects model was used to combine study-specific results. Thirteen cohort 
      studies with 361,686 participants and 11,865 T2DM events were included. Dietary 
      total SFA intake, as well as dietary palmitic acid (PA) or stearic acid (SA) were 
      not associated with risk of T2DM when the highest was compared with the lowest 
      intake category (HR = 0.99; 95% CI: 0.91, 1.09; n = 13 for total SFAs; HR = 0.96; 
      95% CI: 0.79, 1.15; n = 4 for PA; and HR = 1.08; 95% CI: 0.79, 1.49; n = 4 for 
      SA). However, the risk of T2DM decreased by 11% in the highest compared with the 
      lowest category of dietary lauric acid (HR = 0.89; 95% CI: 0.82, 0.97; n = 2), 
      and by 17% in the highest compared with lowest category of dietary myristic acid 
      (MA) (HR = 0.83; 95% CI: 0.74, 0.92; n = 3). There was evidence of publication 
      bias among studies on dietary total SFAs and T2DM. Our results indicated no 
      significant association between dietary total SFA and risk of T2DM. However, 
      dietary intake of MA was negatively associated with developing T2DM.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      American Society for Nutrition.
FAU - Gaeini, Zahra
AU  - Gaeini Z
AD  - Nutrition and Endocrine Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Bahadoran, Zahra
AU  - Bahadoran Z
AD  - Nutrition and Endocrine Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Mirmiran, Parvin
AU  - Mirmiran P
AD  - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, National Nutrition and Food Technology Research Institute, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - Adv Nutr
JT  - Advances in nutrition (Bethesda, Md.)
JID - 101540874
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/etiology/prevention & control
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - Cohort Studies
MH  - Fatty Acids/adverse effects
MH  - Risk Factors
PMC - PMC9776642
OTO - NOTNLM
OT  - diabetes mellitus
OT  - lauric acid
OT  - myristic acid
OT  - palmitic acid
OT  - saturated fats
OT  - stearic acid
EDAT- 2022/09/04 06:00
MHDA- 2022/12/27 06:00
PMCR- 2022/09/03
CRDT- 2022/09/03 10:33
PHST- 2021/07/23 00:00 [received]
PHST- 2021/08/25 00:00 [revised]
PHST- 2022/06/15 00:00 [accepted]
PHST- 2022/09/04 06:00 [pubmed]
PHST- 2022/12/27 06:00 [medline]
PHST- 2022/09/03 10:33 [entrez]
PHST- 2022/09/03 00:00 [pmc-release]
AID - S2161-8313(23)00067-4 [pii]
AID - nmac071 [pii]
AID - 10.1093/advances/nmac071 [doi]
PST - ppublish
SO  - Adv Nutr. 2022 Dec 22;13(6):2125-2135. doi: 10.1093/advances/nmac071.