PMID- 36057168
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20221216
IS  - 1879-2472 (Electronic)
IS  - 0049-3848 (Linking)
VI  - 218
DP  - 2022 Oct
TI  - Postoperative myocardial injury and platelet reactivity in patients undergoing 
      vascular surgery: The platelet reactivity and postoperative myocardial injury 
      after major vascular surgery (PROMISE) study.
PG  - 177-185
LID - S0049-3848(22)00365-6 [pii]
LID - 10.1016/j.thromres.2022.08.023 [doi]
AB  - BACKGROUND: Postoperative myocardial injury (PMI) after major vascular surgery, 
      detected by elevated cardiac troponin (cTn), has been associated with morbidity 
      and mortality. It is unclear whether the pathophysiology of PMI is determined by 
      increased platelet activity. OBJECTIVE: To examine the relationship between 
      platelet activation (P-selectin expression) and PMI in patients undergoing 
      elective open abdominal aortic surgery. METHODS: This prospective, single-centre, 
      observational, cohort study included 33 patients undergoing elective open 
      abdominal aortic surgery between March 2018 and April 2021. Patients were 
      routinely treated with aspirin. Unstimulated platelet activation was measured by 
      platelet bound P-selectin expression (range 0-100 %). Explorative coagulation 
      measurements were: stimulated platelet aggregation measured with the VerifyNow(R) 
      assay (aspirin cartridge), with the Multiplate(R) analyzer (ASPI, ADP and TRAP) and 
      stimulated coagulation status evaluated by the TEG(R) Hemostasis Analyzer System 
      (global hemostasis cartridge). The primary outcome was cTn release assessed by 
      the fifth generation high-sensitive cTn assay. Multivariable generalized linear 
      mixed models were used to evaluate the association between platelet function and 
      cTn concentrations over time. RESULTS: Ten patients (30.3 %) developed PMI. 
      Increased P-selectin expression directly after surgery was associated with the 
      cTn concentrations over 48 h (beta = 1.39 (1.1-1.75), P = 0.0064). No association 
      was found between P-selectin measured later after surgery (at 24 h or 48 h) and 
      cTn concentrations. Furthermore, there was no association between the explorative 
      coagulation parameters and cTn release. CONCLUSION: Platelet reactivity, assessed 
      by P-selectin expression measured directly after surgery is associated with PMI, 
      assessed by elevated cTn concentrations in the early postoperative period in 
      patients undergoing elective open abdominal aortic surgery.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Zheng, K L
AU  - Zheng KL
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Bor, W L
AU  - Bor WL
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Vernooij, L M
AU  - Vernooij LM
AD  - Department of Anaesthesiology, Intensive Care and Pain Medicine, St. Antonius 
      Hospital, Nieuwegein, the Netherlands; Department of Anaesthesiology, Intensive 
      Care and Pain Medicine, University Medical Centre, Utrecht, the Netherlands.
FAU - Breet, N C
AU  - Breet NC
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Kelder, J C
AU  - Kelder JC
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Hackeng, C M
AU  - Hackeng CM
AD  - Department of Clinical Chemistry, St. Antonius Hospital, Nieuwegein, the 
      Netherlands.
FAU - Kropman, R H J
AU  - Kropman RHJ
AD  - Department of Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Ten Berg, J M
AU  - Ten Berg JM
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands; 
      University Medical Centre Maastricht, Maastricht University, Maastricht, the 
      Netherlands.
FAU - Noordzij, P G
AU  - Noordzij PG
AD  - Department of Anaesthesiology, Intensive Care and Pain Medicine, St. Antonius 
      Hospital, Nieuwegein, the Netherlands; Department of Anaesthesiology, Intensive 
      Care and Pain Medicine, University Medical Centre, Utrecht, the Netherlands. 
      Electronic address: p.noordzij@antoniusziekenhuis.nl.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20220828
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 61D2G4IYVH (Adenosine Diphosphate)
RN  - R16CO5Y76E (Aspirin)
RN  - 0 (Diterpenes)
RN  - 0 (P-Selectin)
RN  - 0 (Troponin)
SB  - IM
MH  - Humans
MH  - Adenosine Diphosphate
MH  - Aspirin
MH  - Cohort Studies
MH  - Diterpenes
MH  - *Heart Injuries
MH  - Myocardium
MH  - P-Selectin
MH  - *Platelet Activation
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Troponin
MH  - *Vascular Surgical Procedures/adverse effects
OTO - NOTNLM
OT  - Myocardial injury
OT  - Platelet activitytroponin
OT  - Platelet function
OT  - Vascular surgery
EDAT- 2022/09/04 06:00
MHDA- 2022/09/21 06:00
CRDT- 2022/09/03 18:15
PHST- 2022/07/05 00:00 [received]
PHST- 2022/08/17 00:00 [revised]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/09/04 06:00 [pubmed]
PHST- 2022/09/21 06:00 [medline]
PHST- 2022/09/03 18:15 [entrez]
AID - S0049-3848(22)00365-6 [pii]
AID - 10.1016/j.thromres.2022.08.023 [doi]
PST - ppublish
SO  - Thromb Res. 2022 Oct;218:177-185. doi: 10.1016/j.thromres.2022.08.023. Epub 2022 
      Aug 28.