PMID- 36057822
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20221110
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 89
IP  - 4
DP  - 2022
TI  - Objective Sleep Quality and the Underlying Functional Neural Correlates Among 
      Older Adults with Possible Mild Cognitive Impairment.
PG  - 1473-1482
LID - 10.3233/JAD-220457 [doi]
AB  - BACKGROUND: Poor sleep quality is common among older individuals with mild 
      cognitive impairment (MCI) and may be a consequence of functional alterations in 
      the brain; yet few studies have investigated the underlying neural correlates of 
      actigraphy-measured sleep quality in this cohort. OBJECTIVE: The objective of 
      this study was to examine the relationship between brain networks and sleep 
      quality measured by actigraphy. METHODS: In this cross-sectional analysis, sleep 
      efficiency and sleep fragmentation were estimated using Motionwatch8 (MW8) over a 
      period of 14 days in 36 community-dwelling older adults with possible MCI aged 
      65-85 years. All 36 participants underwent resting-state functional magnetic 
      resonance imaging (fMRI) scanning. Independent associations between network 
      connectivity and MW8 measures of sleep quality were determined using general 
      linear modeling via FSL. Networks examined included the somatosensory network 
      (SMN), frontoparietal network (FPN), and default mode network (DMN). RESULTS: 
      Across the 36 participants (mean age 71.8 years; SD = 5.2 years), mean Montreal 
      Cognitive Assessment score was 22.5 (SD = 2.7) and Mini-Mental State Examination 
      score was 28.3 (SD = 1.5). Mean sleep efficiency and fragmentation index was 
      80.1% (SD = 10.0) and 31.8 (SD = 10.4) respectively. Higher sleep fragmentation 
      was significantly correlated with increased connectivity between the SMN and 
      insula, the SMN and posterior cingulate, as well as FPN and primary motor area 
      (FDR-corrected, p < 0.004). CONCLUSION: Functional connectivity between brain 
      regions involved in attentional and somatosensory processes may be associated 
      with disrupted sleep in older adults with MCI.
FAU - Hsu, Chun Liang
AU  - Hsu CL
AD  - Hinda and Arthur Marcus Institute for Aging Research, Hebrew Senior Life, 
      Roslindale, MA, USA.
AD  - Harvard Medical School, Harvard University, Boston, MA, USA.
AD  - Aging, Mobility, and Cognitive Health Laboratory, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
FAU - Falck, Ryan S
AU  - Falck RS
AD  - Aging, Mobility, and Cognitive Health Laboratory, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
FAU - Backhouse, Daniel
AU  - Backhouse D
AD  - Aging, Mobility, and Cognitive Health Laboratory, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
FAU - Chan, Patrick
AU  - Chan P
AD  - Aging, Mobility, and Cognitive Health Laboratory, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
FAU - Dao, Elizabeth
AU  - Dao E
AD  - Aging, Mobility, and Cognitive Health Laboratory, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
FAU - Ten Brinke, Lisanne F
AU  - Ten Brinke LF
AD  - Aging, Mobility, and Cognitive Health Laboratory, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
FAU - Manor, Brad
AU  - Manor B
AD  - Hinda and Arthur Marcus Institute for Aging Research, Hebrew Senior Life, 
      Roslindale, MA, USA.
AD  - Harvard Medical School, Harvard University, Boston, MA, USA.
FAU - Liu-Ambrose, Teresa
AU  - Liu-Ambrose T
AD  - Aging, Mobility, and Cognitive Health Laboratory, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, 
      Vancouver, BC, Canada.
LA  - eng
GR  - MOP-14220/CIHR/Canada
GR  - PJT-148902/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Aged
MH  - Brain Mapping
MH  - *Cognitive Dysfunction
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Sleep Deprivation
MH  - *Sleep Quality
OTO - NOTNLM
OT  - Mild cognitive impairment
OT  - objective sleep quality
OT  - older adults
OT  - resting-state functional magnetic resonance imaging
EDAT- 2022/09/05 06:00
MHDA- 2022/10/19 06:00
CRDT- 2022/09/04 04:32
PHST- 2022/09/05 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/09/04 04:32 [entrez]
AID - JAD220457 [pii]
AID - 10.3233/JAD-220457 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2022;89(4):1473-1482. doi: 10.3233/JAD-220457.