PMID- 36057907
OWN - NLM
STAT- MEDLINE
DCOM- 20220930
LR  - 20221005
IS  - 1437-9813 (Electronic)
IS  - 0179-0358 (Linking)
VI  - 38
IP  - 11
DP  - 2022 Nov
TI  - Role of urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL), Monocyte 
      Chemoattractant Protein-1(MCP-1), and Interleukin-6(IL-6) as biomarkers in 
      pediatric patients with hydronephrosis.
PG  - 1635-1641
LID - 10.1007/s00383-022-05207-x [doi]
AB  - OBJECTIVES: The decision to surgically intervene in a hydronephrotic kidney in 
      children is based on many debatable guidelines, some requiring repeated 
      ultrasounds or renal scans. Urinary proteins have the potential to reflect renal 
      disorders and hence can be the alternatives to such scans. Here, we aim to assess 
      the role of urinary Neutrophil Gelatinase-Associated Lipocalin, Monocyte 
      Chemoattractant Protein-1, and Interleukin-6 (IL-6) in such patients. METHODS: 
      Seventeen children had obstructive hydronephrosis requiring pyeloplasty (UPJO), 
      while seven were kept on conservative management in view of 
      non-obstructive dilation (NOD). Urine samples were measured for the three urinary 
      proteins at the time of presentation and following pyeloplasty using commercially 
      available ELISA kits. RESULTS: The levels of all three urinary proteins were 
      significantly higher in patients with UPJO children compared to the NOD group. 
      Cut-off values to differentiate obstructive from non-obstructive hydronephrosis 
      were obtained. A significant fall in the post-operative value of urinary IL-6 was 
      also observed. CONCLUSION: This study highlights the potentiality of urinary 
      proteins as biomarkers in identifying children with hydronephrosis and picking 
      out the ones with obstructive hydronephrosis who will require pyeloplasty. The 
      drop in levels after pyeloplasty can be employed to evaluate the effectiveness of 
      pyeloplasty when sent serially.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Suchiang, Biangchwadaka
AU  - Suchiang B
AD  - Department of Pediatric Surgery, All India Institute of Medical Sciences, 
      Jodhpur, India.
FAU - Pathak, Manish
AU  - Pathak M
AD  - Department of Pediatric Surgery, All India Institute of Medical Sciences, 
      Jodhpur, India. pathakm@aiimsjodhpur.edu.in.
FAU - Saxena, Rahul
AU  - Saxena R
AD  - Department of Pediatric Surgery, All India Institute of Medical Sciences, 
      Jodhpur, India.
FAU - Sharma, Shailja
AU  - Sharma S
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Mittal, Aliza
AU  - Mittal A
AD  - Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, 
      India.
FAU - Nayak, Shubhalaxmi
AU  - Nayak S
AD  - Department of Pediatric Surgery, All India Institute of Medical Sciences, 
      Jodhpur, India.
FAU - Jadhav, Avinash
AU  - Jadhav A
AD  - Department of Pediatric Surgery, All India Institute of Medical Sciences, 
      Jodhpur, India.
FAU - Rathod, Kirtikumar
AU  - Rathod K
AD  - Department of Pediatric Surgery, All India Institute of Medical Sciences, 
      Jodhpur, India.
FAU - Sinha, Arvind
AU  - Sinha A
AD  - Department of Pediatric Surgery, All India Institute of Medical Sciences, 
      Jodhpur, India.
LA  - eng
PT  - Journal Article
DEP - 20220904
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
SB  - IM
MH  - Biomarkers/urine
MH  - Chemokine CCL2/*urine
MH  - Child
MH  - Humans
MH  - *Hydronephrosis/diagnosis/surgery
MH  - Interleukin-6/*urine
MH  - Lipocalin-2/*urine
OTO - NOTNLM
OT  - Hydronephrosis
OT  - Interleukin-6 (IL-6)
OT  - Monocyte Chemoattractant Protein-1 (MCP-1)
OT  - Neutrophil Gelatinase-Associated Lipocalin (NGAL)
EDAT- 2022/09/05 06:00
MHDA- 2022/10/01 06:00
CRDT- 2022/09/04 13:57
PHST- 2022/08/26 00:00 [accepted]
PHST- 2022/09/05 06:00 [pubmed]
PHST- 2022/10/01 06:00 [medline]
PHST- 2022/09/04 13:57 [entrez]
AID - 10.1007/s00383-022-05207-x [pii]
AID - 10.1007/s00383-022-05207-x [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2022 Nov;38(11):1635-1641. doi: 10.1007/s00383-022-05207-x. 
      Epub 2022 Sep 4.