PMID- 36058272
OWN - NLM
STAT- MEDLINE
DCOM- 20221011
LR  - 20221212
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 215
IP  - Pt 1
DP  - 2022 Dec
TI  - Association between co-exposure to phenols and phthalates mixture and infertility 
      risk in women.
PG  - 114244
LID - S0013-9351(22)01571-7 [pii]
LID - 10.1016/j.envres.2022.114244 [doi]
AB  - BACKGROUND: Exposure to phenols and phthalates has been separately linked to 
      increased risks of infertility in women of reproductive age. However, the 
      combined effect of phenols and phthalates exposure on infertility has not been 
      explored. METHODS: Data from the National Health and Nutrition Examination 
      Surveys (NHANES) were used. A total of 857 women of reproductive age (18-45 
      years) with available information on urinary phenol and phthalate metabolites, 
      reproductive questionnaires, and covariates were included in the present study. 
      The definition of infertility was based on self-reports. Multivariable logistic 
      regression, principal component analysis (PCA), and Bayesian kernel machine 
      regression (BKMR) with stratified variable selection were applied to determine 
      what associations were found between combined exposure to these mixtures and risk 
      of infertility among women of reproductive age. RESULTS: After adjusting for 
      potential confounders, bisphenol A (BPA), mono(3-carboxypropyl) phthalate (MCPP) 
      and four di(2-ethylhexyl) phthalate (DEHP) metabolites [mono(2-ethylhexyl) 
      phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), 
      mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono(2-ethyl-5-carboxypentyl) 
      phthalate (MECPP)] were positively associated with infertility. PCA revealed that 
      the DEHP-BPA factor's PC score was significantly positively related to the 
      likelihood of infertility [adjusted odds ratio (aOR) = 1.45; 1.08, 1.82]. The 
      DEHP-BPA component consistently had the highest group posterior inclusion 
      probability (PIP) in BKMR models. The BKMR model also found that MEOHP, MEHHP, 
      and BPA were positively associated with infertility risk when the remaining 
      combination concentrations were held at their median values. In addition, we 
      observed that the probability of infertility increased dramatically as the 
      quantiles of total mixture concentration increased. CONCLUSION: Our findings 
      indicate that a combination of phenol and phthalate metabolites is linked to 
      infertility among reproductive-age women. BPA and DEHP, in particular, are 
      significantly related to the risk of infertility.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zhan, Wenqiang
AU  - Zhan W
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China; School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Yang, Hua
AU  - Yang H
AD  - Hainan Women and Children's Medical Center, Haikou, Hainan, China.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China; School of Public Health, Shanghai Jiao Tong University School of Medicine, 
      Shanghai, China.
FAU - Chen, Qian
AU  - Chen Q
AD  - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, 
      Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 
      China. Electronic address: chenqian01@xinhuamed.com.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220902
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phenols)
RN  - 0 (Phthalic Acids)
RN  - 339NCG44TV (Phenol)
RN  - 6O7F7IX66E (phthalic acid)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
RN  - FU2EWB60RT (mono-(2-ethylhexyl)phthalate)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bayes Theorem
MH  - Benzhydryl Compounds
MH  - *Diethylhexyl Phthalate/analogs & derivatives
MH  - Environmental Exposure/adverse effects/analysis
MH  - *Environmental Pollutants/analysis
MH  - Female
MH  - Humans
MH  - *Infertility
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Phenol
MH  - Phenols/analysis/toxicity
MH  - *Phthalic Acids/metabolism/toxicity
MH  - Young Adult
OTO - NOTNLM
OT  - BPA
OT  - Co-exposure
OT  - DEHP
OT  - Infertility
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/09/05 06:00
MHDA- 2022/10/12 06:00
CRDT- 2022/09/04 19:23
PHST- 2022/05/31 00:00 [received]
PHST- 2022/08/09 00:00 [revised]
PHST- 2022/08/29 00:00 [accepted]
PHST- 2022/09/05 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/09/04 19:23 [entrez]
AID - S0013-9351(22)01571-7 [pii]
AID - 10.1016/j.envres.2022.114244 [doi]
PST - ppublish
SO  - Environ Res. 2022 Dec;215(Pt 1):114244. doi: 10.1016/j.envres.2022.114244. Epub 
      2022 Sep 2.