PMID- 36058784
OWN - NLM
STAT- MEDLINE
DCOM- 20230126
LR  - 20230227
IS  - 1878-4380 (Electronic)
IS  - 0966-842X (Linking)
VI  - 31
IP  - 2
DP  - 2023 Feb
TI  - The microbiome in HLA-B27-associated disease: implications for acute anterior 
      uveitis and recommendations for future studies.
PG  - 142-158
LID - S0966-842X(22)00220-7 [pii]
LID - 10.1016/j.tim.2022.08.008 [doi]
AB  - The pathogenesis of human leukocyte antigen (HLA)-B27-associated diseases such as 
      acute anterior uveitis (AAU) and ankylosing spondylitis (AS) remains poorly 
      understood, though Gram-negative bacteria and subclinical bowel inflammation are 
      strongly implicated. Accumulating evidence from animal models and clinical 
      studies supports several hypotheses, including HLA-B27-dependent dysbiosis, 
      altered intestinal permeability, and molecular mimicry. However, the existing 
      literature is hampered by inadequate studies designed to establish causation or 
      uncover the role of viruses and fungi. Moreover, the unique disease model 
      afforded by AAU to study the gut microbiota has been neglected. This review 
      critically evaluates the current literature and prevailing hypotheses on the link 
      between the gut microbiota and HLA-B27-associated disease. We propose a new 
      potential role for HLA-B27-driven altered antibody responses to gut microbiota in 
      disease pathogenesis and outline recommendations for future well-controlled human 
      studies, focusing on AAU.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Parthasarathy, Rohit
AU  - Parthasarathy R
AD  - School of Medical Sciences, Faculty of Medicine & Health, UNSW, Sydney, 
      Australia.
FAU - Santiago, Fernando
AU  - Santiago F
AD  - School of Medical Sciences, Faculty of Medicine & Health, UNSW, Sydney, 
      Australia.
FAU - McCluskey, Peter
AU  - McCluskey P
AD  - Save Sight Institute, Sydney Eye Hospital, Sydney, Australia; Faculty of Medicine 
      and Health, The University of Sydney, Sydney, Australia.
FAU - Kaakoush, Nadeem O
AU  - Kaakoush NO
AD  - School of Medical Sciences, Faculty of Medicine & Health, UNSW, Sydney, 
      Australia.
FAU - Tedla, Nicodemus
AU  - Tedla N
AD  - School of Medical Sciences, Faculty of Medicine & Health, UNSW, Sydney, 
      Australia.
FAU - Wakefield, Denis
AU  - Wakefield D
AD  - School of Medical Sciences, Faculty of Medicine & Health, UNSW, Sydney, 
      Australia; Center for Immunology and Immunopathology, South Eastern Area Health 
      Service, Sydney, Australia. Electronic address: d.wakefield@unsw.edu.au.
LA  - eng
SI  - ClinicalTrials.gov/NCT01330901
SI  - ClinicalTrials.gov/NCT03726645
SI  - ClinicalTrials.gov/NCT03058900
PT  - Journal Article
PT  - Review
DEP - 20220901
PL  - England
TA  - Trends Microbiol
JT  - Trends in microbiology
JID - 9310916
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Animals
MH  - Humans
MH  - HLA-B27 Antigen/genetics
MH  - *Uveitis, Anterior/complications/pathology
MH  - *Spondylitis, Ankylosing/complications
MH  - *Microbiota
MH  - *Gastrointestinal Microbiome
MH  - Acute Disease
OTO - NOTNLM
OT  - HLA-B27
OT  - acute anterior uveitis
OT  - gut microbiome
OT  - human leukocyte antigens
OT  - inflammatory bowel diseases
OT  - spondyloarthropathy
COIS- Declaration of interests No interests are declared.
EDAT- 2022/09/05 06:00
MHDA- 2023/01/27 06:00
CRDT- 2022/09/04 22:05
PHST- 2022/05/19 00:00 [received]
PHST- 2022/08/09 00:00 [revised]
PHST- 2022/08/09 00:00 [accepted]
PHST- 2022/09/05 06:00 [pubmed]
PHST- 2023/01/27 06:00 [medline]
PHST- 2022/09/04 22:05 [entrez]
AID - S0966-842X(22)00220-7 [pii]
AID - 10.1016/j.tim.2022.08.008 [doi]
PST - ppublish
SO  - Trends Microbiol. 2023 Feb;31(2):142-158. doi: 10.1016/j.tim.2022.08.008. Epub 
      2022 Sep 1.