PMID- 36058853
OWN - NLM
STAT- MEDLINE
DCOM- 20220907
LR  - 20220907
IS  - 0485-1439 (Print)
IS  - 0485-1439 (Linking)
VI  - 63
IP  - 8
DP  - 2022
TI  - [Haploidentical hematopoietic stem cell transplantation for graft failure in 
      myelodysplastic syndrome/myeloproliferative neoplasm-unclassifiable complicated 
      with Stenotrophomonas maltophilia bacteremia].
PG  - 849-854
LID - 10.11406/rinketsu.63.849 [doi]
AB  - A 60-year-old woman with myelodysplastic syndrome/myeloproliferative 
      neoplasm-unclassifiable underwent unrelated bone marrow transplantation from a 
      human leukocyte antigen (HLA) 8/8 allele-matched male donor. Neutrophil 
      engraftment was achieved on day 29. Fluorescence in situ hybridization of sex 
      chromosomes demonstrated complete donor chimerism. The red blood cell and 
      platelet transfusion dependence continued, and the neutrophil count decreased 
      gradually. Despite prolonged administration of broad-spectrum antibiotics for 
      febrile neutropenia, blood cultures on days 46 and 58 returned positive for 
      Stenotrophomonas maltophilia (SM). Contrast-enhanced computed tomography revealed 
      multiple nodules of septic emboli in the lungs and kidneys, suggesting a 
      disseminated SM infection. Antibiotic therapy was conducted based on 
      antimicrobial susceptibility testing. However, the blood cell count failed to 
      normalize and a secondary graft failure was diagnosed. A HLA-haploidentical 
      peripheral-blood stem-cell transplantation from the patient's son was performed 
      on day 134 after the initial transplantation. Neutrophil engraftment was achieved 
      on day 11. Red blood cells and platelets were also engrafted. After the 
      resolution of the SM bacteremia, the patient was discharged on day 63. The 
      prognosis of the SM bacteremia with neutropenia is poor. Antibiotic treatment 
      based on antimicrobial susceptibility testing and a second transplant from an 
      HLA-haploidentical donor likely contributed to the successful outcome in this 
      patient.
FAU - Mukae, Junichi
AU  - Mukae J
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Sekiya, Noritaka
AU  - Sekiya N
AD  - Department of Infection Prevention and Control, Tokyo Metropolitan Cancer and 
      Infectious Diseases Center, Komagome Hospital.
AD  - Department of Clinical Laboratory, Tokyo Metropolitan Cancer and Infectious 
      Diseases Center, Komagome Hospital.
FAU - Kato, Chika
AU  - Kato C
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Sakai, Satoshi
AU  - Sakai S
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Nakashima, Shiori
AU  - Nakashima S
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Murakami, Daisuke
AU  - Murakami D
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Kambara, Yasuhiro
AU  - Kambara Y
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Atsuta, Yuya
AU  - Atsuta Y
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Konuma, Ryosuke
AU  - Konuma R
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Wada, Atsushi
AU  - Wada A
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Uchibori, Yusuke
AU  - Uchibori Y
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Onai, Daishi
AU  - Onai D
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Nishijima, Akihiko
AU  - Nishijima A
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Noguchi, Yuma
AU  - Noguchi Y
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Shingai, Naoki
AU  - Shingai N
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Toya, Takashi
AU  - Toya T
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Shimizu, Hiroaki
AU  - Shimizu H
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Najima, Yuho
AU  - Najima Y
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Kobayashi, Takeshi
AU  - Kobayashi T
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Sakamaki, Hisashi
AU  - Sakamaki H
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Ohashi, Kazuteru
AU  - Ohashi K
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
FAU - Doki, Noriko
AU  - Doki N
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Rinsho Ketsueki
JT  - [Rinsho ketsueki] The Japanese journal of clinical hematology
JID - 2984782R
RN  - 0 (Anti-Infective Agents)
RN  - Stenotrophomonas maltophilia bacteremia
SB  - IM
MH  - *Anti-Infective Agents
MH  - *Bacteremia/etiology
MH  - Female
MH  - Gram-Negative Bacterial Infections
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - *Myelodysplastic Syndromes/complications/therapy
MH  - *Myelodysplastic-Myeloproliferative Diseases
MH  - *Neoplasms
MH  - *Stenotrophomonas maltophilia/immunology
OTO - NOTNLM
OT  - Haploidentical hematopoietic stem cell transplantation
OT  - Secondary graft failure
OT  - Stenotrophomonas maltophilia bacteremia
EDAT- 2022/09/05 06:00
MHDA- 2022/09/08 06:00
CRDT- 2022/09/04 22:23
PHST- 2022/09/04 22:23 [entrez]
PHST- 2022/09/05 06:00 [pubmed]
PHST- 2022/09/08 06:00 [medline]
AID - 10.11406/rinketsu.63.849 [doi]
PST - ppublish
SO  - Rinsho Ketsueki. 2022;63(8):849-854. doi: 10.11406/rinketsu.63.849.