PMID- 36059323
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220907
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 8
DP  - 2022 Aug
TI  - Colon Cancer and Obesity: A Narrative Review.
PG  - e27589
LID - 10.7759/cureus.27589 [doi]
LID - e27589
AB  - Obesity has played a crucial role in the pathogenesis of various cancers, 
      including colorectal cancer (CRC). Obesity has shown to increase the blood levels 
      of insulin, insulin-like growth factor-1 (IGF-1), leptin, resistin, inflammatory 
      cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), 
      monocyte chemoattractant protein-1 (MCP-1) which in turn acts via various 
      signaling pathways to induce colonic cell proliferation and in turn CRC 
      development. It has been shown that estrogen can prevent and cause CRC based on 
      which receptor it acts. Obese patients have relatively low levels of ghrelin and 
      adiponectin that inhibit cell proliferation which further adds to their risk of 
      developing CRC. Obesity can alter the microbial flora of the gut in such a way as 
      to favor carcinogenesis. Weight loss and good physical activity have been related 
      to a reduced incidence of CRC; obese individuals should be screened for CRC and 
      counseled about the importance of weight reduction, diet, and exercise. The best 
      way of screening is using BMI and waist circumference (WC) to calculate the CRC 
      risk in obese people. This study has reviewed the association between obesity and 
      its pathophysiological association with CRC development.
CI  - Copyright (c) 2022, Duraiyarasan et al.
FAU - Duraiyarasan, Shrimahitha
AU  - Duraiyarasan S
AD  - Research, K.A.P. Viswanatham Government Medical College, Tiruchirappalli, IND.
FAU - Adefuye, Mayowa
AU  - Adefuye M
AD  - Research, University of Ibadan College of Medicine, Ibadan, NGA.
FAU - Manjunatha, Nisha
AU  - Manjunatha N
AD  - Research, Our Lady of Fatima University College of Medicine, Metro Manila, PHL.
FAU - Ganduri, Vinutna
AU  - Ganduri V
AD  - Research, Bhaskar Medical College, Hyderabad, IND.
FAU - Rajasekaran, Kruthiga
AU  - Rajasekaran K
AD  - Research, Rajah Muthiah Medical College and Hospital, Chidambaram, IND.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220801
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9433794
OTO - NOTNLM
OT  - colorectal cancer (crc)
OT  - estrogen and crc
OT  - ghrelin and crc
OT  - obesity and cancer
OT  - obesity and inflammatory markers
OT  - obesity and mutation
OT  - oxidative dna damage
OT  - resistin and cancer
OT  - role of gut microbiomes in cancer
OT  - role of obesity and diabetes
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/09/06 06:00
MHDA- 2022/09/06 06:01
PMCR- 2022/08/01
CRDT- 2022/09/05 03:34
PHST- 2022/07/30 00:00 [accepted]
PHST- 2022/09/05 03:34 [entrez]
PHST- 2022/09/06 06:00 [pubmed]
PHST- 2022/09/06 06:01 [medline]
PHST- 2022/08/01 00:00 [pmc-release]
AID - 10.7759/cureus.27589 [doi]
PST - epublish
SO  - Cureus. 2022 Aug 1;14(8):e27589. doi: 10.7759/cureus.27589. eCollection 2022 Aug.