PMID- 36060429 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231105 IS - 2090-8016 (Print) IS - 2090-0597 (Electronic) IS - 2090-0597 (Linking) VI - 2022 DP - 2022 TI - The Effect of TNF-alpha on CHD and the Relationship between TNF-alpha Antagonist and CHD in Rheumatoid Arthritis: A Systematic Review. PG - 6192053 LID - 10.1155/2022/6192053 [doi] LID - 6192053 AB - Tumor necrosis factor-alpha (TNF-alpha) plays an important role in coronary heart disease (CHD), a chronic inflammatory process. Meanwhile, this pro-inflammatory factor is also involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Patients with RA correspond to a higher risk of CHD. TNF-alpha antagonist, one of the main treatments for RA, may reduce the risk of CHD in patients with RA. This review summarizes the pathogenesis of TNF-alpha in CHD and discusses the relationship between TNF-alpha antagonist and CHD in patients with RA. CI - Copyright (c) 2022 Yezhou Qian et al. FAU - Qian, Yezhou AU - Qian Y AD - Department of Cardiology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China. FAU - Mao, Menghui AU - Mao M AD - Department of Cardiology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China. FAU - Nian, Feige AU - Nian F AUID- ORCID: 0000-0002-6261-6682 AD - Department of Rheumatology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China. LA - eng PT - Journal Article PT - Review DEP - 20220824 PL - United States TA - Cardiol Res Pract JT - Cardiology research and practice JID - 101516542 PMC - PMC9433296 COIS- The authors declare that they have no conflicts of interest. EDAT- 2022/09/06 06:00 MHDA- 2022/09/06 06:01 PMCR- 2022/08/24 CRDT- 2022/09/05 03:53 PHST- 2022/05/28 00:00 [received] PHST- 2022/07/27 00:00 [revised] PHST- 2022/07/29 00:00 [accepted] PHST- 2022/09/05 03:53 [entrez] PHST- 2022/09/06 06:00 [pubmed] PHST- 2022/09/06 06:01 [medline] PHST- 2022/08/24 00:00 [pmc-release] AID - 10.1155/2022/6192053 [doi] PST - epublish SO - Cardiol Res Pract. 2022 Aug 24;2022:6192053. doi: 10.1155/2022/6192053. eCollection 2022.