PMID- 36060644
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220907
IS  - 2391-5412 (Electronic)
IS  - 2391-5412 (Linking)
VI  - 17
IP  - 1
DP  - 2022
TI  - Aberrant pulmonary immune response of obese mice to periodontal infection.
PG  - 991-1000
LID - 10.1515/biol-2022-0089 [doi]
AB  - Obesity and periodontitis constitute mutual risk factors in respiratory 
      disorders; this study aimed to explore the pulmonary immune response to 
      periodontal infection using combined animal models with diet-induced obesity 
      (DIO). Thirty-two C57 BL/6J mice were randomly divided into low-fat (LF) or 
      high-fat (HF) diet groups and fed an LF diet as a control or an HF diet to induce 
      obesity. The 30-week mice in the diet group were divided into periodontal 
      ligation group (10 days using Porphyromonas gingivalis ATCC 33277) or 
      sham-ligation group. The expressions of the macrophage-specific maker (F4/80), 
      macrophage chemotactic protein1 (MCP1), and inflammatory cytokines in lung 
      tissues were analyzed. The mRNA and protein levels of F4/80, MCP1, interleukin 
      (IL)-1beta, and IL-6 expressions were significantly upregulated by obesity in lung 
      tissues. However, the mRNA and protein levels of F4/80, MCP1, and IL-6 were 
      downregulated by periodontitis in DIO mice relative to that of the HF control 
      group. Periodontitis increased tumor necrosis factor-alpha level of lung tissues 
      under LF, while IL-10 was not affected by obesity regardless of periodontitis. 
      Periodontitis may aggravate pulmonary immune response in obese rodents. This may 
      relate to the imbalance of the pro- and anti-inflammatory cytokine status of lung 
      lesions, which tends to attenuate the infiltration of alveolar macrophages.
CI  - (c) 2022 Wei Zhou et al., published by De Gruyter.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Department of Periodontics, Shenzhen Stomatological Hospital, Southern Medical 
      University, Shenzhen, Guangdong, China.
FAU - Xuan, Dongying
AU  - Xuan D
AD  - Southern Medical University, No. 1023-1063, Shatai South Road, Baiyun District, 
      Guangzhou, Guangdong, China.
FAU - Yu, Ting
AU  - Yu T
AD  - Department of Periodontics, Affiliated Stomatology Hospital of Guangzhou Medical 
      University, Guangdong Engineering Research Center of Oral Restoration and 
      Reconstruction, Guangzhou Key laboratory of Basic and Applied Research of Oral 
      Regenerative Medicine, 195A, Dongfeng West Road, Yuexiu District, Guangzhou, 
      Guangdong, China.
FAU - Zhang, Jincai
AU  - Zhang J
AD  - Southern Medical University, No. 1023-1063, Shatai South Road, Baiyun District, 
      Guangzhou, Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20220817
PL  - Poland
TA  - Open Life Sci
JT  - Open life sciences
JID - 101669614
PMC - PMC9386611
OTO - NOTNLM
OT  - diet-induced obesity
OT  - periodontal infection
OT  - pulmonary immune response
COIS- Conflict of interest: Authors state no conflict of interest.
EDAT- 2022/09/06 06:00
MHDA- 2022/09/06 06:01
PMCR- 2022/08/17
CRDT- 2022/09/05 03:57
PHST- 2022/01/06 00:00 [received]
PHST- 2022/05/16 00:00 [revised]
PHST- 2022/05/18 00:00 [accepted]
PHST- 2022/09/05 03:57 [entrez]
PHST- 2022/09/06 06:00 [pubmed]
PHST- 2022/09/06 06:01 [medline]
PHST- 2022/08/17 00:00 [pmc-release]
AID - biol-2022-0089 [pii]
AID - 10.1515/biol-2022-0089 [doi]
PST - epublish
SO  - Open Life Sci. 2022 Aug 17;17(1):991-1000. doi: 10.1515/biol-2022-0089. 
      eCollection 2022.