PMID- 36060953
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220916
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Antiosteoporosis and bone protective effect of dieckol against 
      glucocorticoid-induced osteoporosis in rats.
PG  - 932488
LID - 10.3389/fendo.2022.932488 [doi]
LID - 932488
AB  - BACKGROUND: Glucocorticoids (GCs) induce osteoporosis, which results in fractures 
      in the bond, causing significant morbidity. In the conducted study, we examined 
      the antiosteoporosis effect of dieckol against GC-induced osteoporosis in rats. 
      METHODS: Sprague-Dawley (SD) rats were used for the current study and 
      dexamethasone (2.5 mg/kg) induced osteoporosis in the rats that received the 
      dieckol (test) and alendronate (standard) for 20 weeks. Bone turnover parameters, 
      microCT, antioxidant, inflammatory cytokines, nutrient, and hormones parameters. 
      RESULTS: Dieckol noticeably suppressed the body weight and boosted the uterine 
      and vagina weight. Dieckol considerably altered the level of trabecular number 
      (Tb. N), the bone volume to total volume (BV/TV), trabecular separation (Tb.Sp), 
      bone surface to bone volume (BS/BV), and t​r​a​b​e​c​u​l​a​r thickness (Tb.Th). 
      Dieckol noticeably (P < 0.001) elevated the level of osteocalcin (OC) and 
      alleviated the level of bone Gla protein (BGP), acid phosphatase (ACP), alkaline 
      phosphatase (ALP), and beta-CTx. Dieckol markedly boosted the level of 
      malondialdehyde (MDA) and suppressed the level of glutathione (GSH), catalase 
      (CAT), and superoxide dismutase (SOD) along with the suppression of inflammatory 
      cytokines like TNF-alpha, IL-1beta, and IL-6. Dieckol remarkably increased the level of 
      calcium, potassium, magnesium, and 25 (OH) vitamin D. Dieckol substantially (P < 
      0.001) boosted the level of estradiol and alleviated the level of parathyroid 
      hormone and tartrate-resistant acid phosphatase (TRAP). Dieckol also suppressed 
      the level of receptor activator of nuclear factor kappaB ligand (RANKL) and boosted 
      the level of osteoprotegerin (OPG). CONCLUSION: Taken together, our data suggest 
      that dieckol demonstrated the anti-osteoporosis effect against GC-induced 
      osteoporosis in rats.
CI  - Copyright (c) 2022 Wang, Yang and Chao.
FAU - Wang, Hao
AU  - Wang H
AD  - Department of Orthopedics, Xian Yang Central Hospital, Xianyang, China.
FAU - Yang, Leigang
AU  - Yang L
AD  - Department of Orthopedics, Xian Yang Central Hospital, Xianyang, China.
FAU - Chao, Junwei
AU  - Chao J
AD  - Department of Orthopedics, Xian Yang Central Hospital, Xianyang, China.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Benzofurans)
RN  - 0 (Cytokines)
RN  - 0 (Glucocorticoids)
RN  - 0 (dieckol)
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Animals
MH  - *Benzofurans/therapeutic use
MH  - Cytokines
MH  - Female
MH  - *Glucocorticoids/adverse effects
MH  - Osteocalcin
MH  - *Osteoporosis/chemically induced/drug therapy/prevention & control
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC9437630
OTO - NOTNLM
OT  - antioxidant
OT  - bone turnover parameter
OT  - dieckol
OT  - hormone
OT  - inflammation
OT  - osteoporosis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/06 06:00
MHDA- 2022/09/09 06:00
PMCR- 2022/01/01
CRDT- 2022/09/05 04:01
PHST- 2022/04/29 00:00 [received]
PHST- 2022/06/27 00:00 [accepted]
PHST- 2022/09/05 04:01 [entrez]
PHST- 2022/09/06 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.932488 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Aug 19;13:932488. doi: 
      10.3389/fendo.2022.932488. eCollection 2022.