PMID- 36060972
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220914
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes 
      mellitus.
PG  - 976465
LID - 10.3389/fendo.2022.976465 [doi]
LID - 976465
AB  - Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic 
      metabolic diseases worldwide, which poses a great threat to human safety and 
      health. The main feature of T2DM is the deterioration of pancreatic beta-cell 
      function. More and more studies have shown that the decline of pancreatic 
      beta-cell function in T2DM can be attributable to beta-cell apoptosis, but the 
      exact mechanisms of beta-cell apoptosis in T2DM are not yet fully clarified. 
      Therefore, in this review, we will focus on the current status and progress of 
      research on the mechanism of pancreatic beta-cell apoptosis in T2DM, to provide 
      new ideas for T2DM treatment strategies.
CI  - Copyright (c) 2022 You, Zheng, Chen and Huang.
FAU - You, SuFang
AU  - You S
AD  - The Second Clinical Medical College of Fujian Medical University, Quanzhou, 
      China.
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, China.
FAU - Zheng, JingYi
AU  - Zheng J
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, China.
FAU - Chen, YuPing
AU  - Chen Y
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, China.
FAU - Huang, HuiBin
AU  - Huang H
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220818
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Apoptosis
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Humans
MH  - *Insulin-Secreting Cells/metabolism
MH  - Pancreas/metabolism
PMC - PMC9434279
OTO - NOTNLM
OT  - apoptosis
OT  - beta-cell
OT  - exosomes
OT  - glucolipotoxicity
OT  - molecular mechanisms
OT  - non-coding RNAs
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/06 06:00
MHDA- 2022/09/09 06:00
PMCR- 2022/01/01
CRDT- 2022/09/05 04:01
PHST- 2022/06/23 00:00 [received]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2022/09/05 04:01 [entrez]
PHST- 2022/09/06 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.976465 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Aug 18;13:976465. doi: 
      10.3389/fendo.2022.976465. eCollection 2022.