PMID- 36062296
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220907
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2022
DP  - 2022
TI  - Influence of Preoperative Foveal Layers' Thickness on Visual Function and Macular 
      Morphology by Phacovitrectomy for Epiretinal Membrane.
PG  - 1895498
LID - 10.1155/2022/1895498 [doi]
LID - 1895498
AB  - BACKGROUND: The aim of this retrospective study with short, differently dispersed 
      follow-up is to record the relationships between the pathologies of the 
      individual foveal layers, measured by spectral domain optical coherence 
      tomography (SD-OCT), and to investigate their influence on pre- and postoperative 
      best-corrected decimal far visual acuity (BCVA) by phacovitrectomy for epiretinal 
      membrane (ERM) in comorbidity with cataract. Patients and Methods. 208 eyes of 
      173 patients with symptomatic idiopathic ERM and moderate cataract were included. 
      RESULTS: In all OCT morphological stages of ERM, as well as in their combination 
      with macular lamellar hole (MLH) and vitreomacular traction (VMT), a significant 
      difference in the thickness of the individual fovea layers was found. In 
      addition, the entire fovea thickening led to the proportional thickening of the 
      individual fovea layers (p < 0.001). The larger the central foveolar (CFT, R 
      (2) = -0.238, p=0.002), maximum foveal (MFT, R (2) = -0.267, p=0.001), and ONL 
      thickness (R (2) = -0.16, p=0.044) were preoperatively, the worse the initial 
      visual acuity was at all OCT stages of ERM. This was even more significant in the 
      presence of a tractive component in the case of MLH or VMT (p < 0.001). In ERM 
      without a traction component, only ONL thickening led to significant 
      postoperative visual acuity reduction (R (2) = -0.163, p=0.047). The foveolar 
      retinal thickening (CFT and MFT) of the pure ERM is directly associated with 
      distortion of the retinal layers (R (2) = 0.292, p < 0.001 and R (2) = 0.287, p < 
      0.001) as well as with separation of the ERM (R (2) = 0.168, p=0.034 and R 
      (2) = 0.187, p=0.018). When ERM was combined with tractive component, CFT, ONL, 
      and INL thickness correlated (positively) with the integrity of ellipsoid zone (R 
      (2) = 0.342, p < 0.05) and external limiting membrane (R (2) = 0.548, p < 0.001). 
      CONCLUSIONS: ONL thickening in ERM without a tractive component serves as a 
      limited prognostic factor of postoperative visual acuity decrease. The 
      preoperative BCVA in the groups of ERM with traction component showed significant 
      correlation with CFT as well as with the thickness of individual foveal layers. 
      VMT in ERM correlates with the disintegration of the ellipsoid zone.
CI  - Copyright (c) 2022 R Zhmurin et al.
FAU - Zhmurin, R
AU  - Zhmurin R
AUID- ORCID: 0000-0001-6016-5833
AD  - Department of Ophthalmology of the Municipal Hospital Dessau, Academic Teaching 
      Hospital with University Departments of the Brandenburg Medical School Theodor 
      Fontane, Brandenburg, Germany.
AD  - Charite-Universitatsmedizin, Berlin, Germany.
FAU - Grajewski, L
AU  - Grajewski L
AD  - Department of Ophthalmology of the Municipal Hospital Dessau, Academic Teaching 
      Hospital with University Departments of the Brandenburg Medical School Theodor 
      Fontane, Brandenburg, Germany.
FAU - Krause, L
AU  - Krause L
AD  - Department of Ophthalmology of the Municipal Hospital Dessau, Academic Teaching 
      Hospital with University Departments of the Brandenburg Medical School Theodor 
      Fontane, Brandenburg, Germany.
AD  - Charite-Universitatsmedizin, Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20220825
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC9436612
COIS- The authors of this article did not receive any financial support directly or 
      indirectly during the research process. They declare that they have no conflicts 
      of interest regarding the publication of this paper.
EDAT- 2022/09/06 06:00
MHDA- 2022/09/06 06:01
PMCR- 2022/08/25
CRDT- 2022/09/05 04:23
PHST- 2022/03/24 00:00 [received]
PHST- 2022/07/01 00:00 [revised]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/09/05 04:23 [entrez]
PHST- 2022/09/06 06:00 [pubmed]
PHST- 2022/09/06 06:01 [medline]
PHST- 2022/08/25 00:00 [pmc-release]
AID - 10.1155/2022/1895498 [doi]
PST - epublish
SO  - J Ophthalmol. 2022 Aug 25;2022:1895498. doi: 10.1155/2022/1895498. eCollection 
      2022.