PMID- 36062861 OWN - NLM STAT- MEDLINE DCOM- 20220928 LR - 20230517 IS - 1930-739X (Electronic) IS - 1930-7381 (Linking) VI - 30 IP - 10 DP - 2022 Oct TI - Effect of low skeletal muscle mass and sarcopenic obesity on chronic kidney disease in patients with type 2 diabetes. PG - 2034-2043 LID - 10.1002/oby.23512 [doi] AB - OBJECTIVE: This study aimed to investigate the association between low muscle mass or sarcopenic obesity and the risk of incident chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 3123 patients with T2DM with preserved renal function were followed up for incident CKD. Skeletal muscle mass was estimated from bioelectrical impedance analysis. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m(2) . Sarcopenic obesity was defined as the coexistence of sarcopenia and abdominal obesity. RESULTS: During 8.9 years of follow-up, 530 (17.0%) patients developed incident CKD. When patients were divided into three groups based on sex-specific tertiles, lower muscle mass was not associated with an increased risk of incident CKD after adjustment for risk factors. However, when patients were divided into four groups according to the presence of sarcopenia and obesity, sarcopenic obesity was associated with an increased risk of incident CKD (adjusted hazard ratio 1.77; 95% CI: 1.24-2.51; p = 0.001) compared with the other groups. CONCLUSIONS: Sarcopenic obesity, but not low muscle mass alone, may increase the risk of CKD in patients with T2DM. CI - (c) 2022 The Obesity Society. FAU - Seo, Da Hea AU - Seo DH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea. FAU - Suh, Young Ju AU - Suh YJ AD - Department of Biomedical Sciences, Inha University College of Medicine, Incheon, Republic of Korea. FAU - Cho, Yongin AU - Cho Y AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea. FAU - Ahn, Seong Hee AU - Ahn SH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea. FAU - Seo, Seongha AU - Seo S AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea. FAU - Hong, Seongbin AU - Hong S AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea. FAU - Lee, Yong-Ho AU - Lee YH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Choi, Young Ju AU - Choi YJ AD - Huh's Diabetes Center, Seoul, Republic of Korea. FAU - Lee, Eunjig AU - Lee E AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Kim, So Hun AU - Kim SH AUID- ORCID: 0000-0002-2554-3664 AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220905 PL - United States TA - Obesity (Silver Spring) JT - Obesity (Silver Spring, Md.) JID - 101264860 SB - IM CIN - Obesity (Silver Spring). 2023 May;31(5):1177. PMID: 36977655 CIN - Obesity (Silver Spring). 2023 May;31(5):1178. PMID: 37013909 MH - *Diabetes Mellitus, Type 2/complications/epidemiology MH - Female MH - Humans MH - Male MH - Muscle, Skeletal MH - Obesity/complications MH - *Renal Insufficiency, Chronic/complications/epidemiology MH - Risk Factors MH - *Sarcopenia/complications/epidemiology EDAT- 2022/09/06 06:00 MHDA- 2022/09/28 06:00 CRDT- 2022/09/05 07:24 PHST- 2022/05/09 00:00 [revised] PHST- 2022/03/10 00:00 [received] PHST- 2022/05/18 00:00 [accepted] PHST- 2022/09/06 06:00 [pubmed] PHST- 2022/09/28 06:00 [medline] PHST- 2022/09/05 07:24 [entrez] AID - 10.1002/oby.23512 [doi] PST - ppublish SO - Obesity (Silver Spring). 2022 Oct;30(10):2034-2043. doi: 10.1002/oby.23512. Epub 2022 Sep 5.