PMID- 36062877
OWN - NLM
STAT- MEDLINE
DCOM- 20221006
LR  - 20231002
IS  - 1522-1563 (Electronic)
IS  - 0363-6143 (Print)
IS  - 0363-6143 (Linking)
VI  - 323
IP  - 4
DP  - 2022 Oct 1
TI  - Role of mechanistic target of rapamycin in autophagy and alcohol-associated liver 
      disease.
PG  - C1100-C1111
LID - 10.1152/ajpcell.00281.2022 [doi]
AB  - Mechanistic target of rapamycin (mTOR) is a serine-threonine kinase and a 
      cellular sensor for nutrient and energy status, which is critical in regulating 
      cell metabolism and growth by governing the anabolic (protein and lipid 
      synthesis) and catabolic process (autophagy). Alcohol-associated liver disease 
      (ALD) is a major chronic liver disease worldwide that carries a huge financial 
      burden. The spectrum of the pathogenesis of ALD includes steatosis, fibrosis, 
      inflammation, ductular reaction, and eventual hepatocellular carcinoma, which is 
      closely associated with metabolic changes that are regulated by mTOR. In this 
      review, we summarized recent progress of alcohol consumption on the changes of 
      mTORC1 and mTORC2 activity, the potential mechanisms and possible impact of the 
      mTORC1 changes on autophagy in ALD. We also discussed the potential beneficial 
      effects and limitations of targeting mTORC1 against ALD.
FAU - Chao, Xiaojuan
AU  - Chao X
AD  - Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas 
      Medical Center, Kansas City, Kansas.
FAU - Williams, Sha Neisha
AU  - Williams SN
AD  - Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas 
      Medical Center, Kansas City, Kansas.
FAU - Ding, Wen-Xing
AU  - Ding WX
AUID- ORCID: 0000-0002-3167-5073
AD  - Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas 
      Medical Center, Kansas City, Kansas.
LA  - eng
GR  - R01 AG072895/AG/NIA NIH HHS/United States
GR  - R01 DK102142/DK/NIDDK NIH HHS/United States
GR  - R37 AA020518/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20220905
PL  - United States
TA  - Am J Physiol Cell Physiol
JT  - American journal of physiology. Cell physiology
JID - 100901225
RN  - 0 (Lipids)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - *Autophagy
MH  - Lipids
MH  - Mechanistic Target of Rapamycin Complex 1/metabolism
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - *Sirolimus
MH  - TOR Serine-Threonine Kinases/genetics/metabolism
PMC - PMC9550572
OTO - NOTNLM
OT  - alcohol-associated liver disease
OT  - autophagy
OT  - ethanol
OT  - mTOR
OT  - transcription factor EB
COIS- No conflicts of interest, financial or otherwise, are declared by the authors.
EDAT- 2022/09/06 06:00
MHDA- 2022/10/07 06:00
PMCR- 2023/10/01
CRDT- 2022/09/05 07:32
PHST- 2022/09/06 06:00 [pubmed]
PHST- 2022/10/07 06:00 [medline]
PHST- 2022/09/05 07:32 [entrez]
PHST- 2023/10/01 00:00 [pmc-release]
AID - C-00281-2022 [pii]
AID - 10.1152/ajpcell.00281.2022 [doi]
PST - ppublish
SO  - Am J Physiol Cell Physiol. 2022 Oct 1;323(4):C1100-C1111. doi: 
      10.1152/ajpcell.00281.2022. Epub 2022 Sep 5.