PMID- 36063357
OWN - NLM
STAT- MEDLINE
DCOM- 20221005
LR  - 20221112
IS  - 0975-0711 (Electronic)
IS  - 0254-8860 (Linking)
VI  - 41
IP  - 4
DP  - 2022 Aug
TI  - Thromboembolism is associated with poor prognosis and high mortality in patients 
      with inflammatory bowel disease: A case-control study.
PG  - 325-335
LID - 10.1007/s12664-021-01237-w [doi]
AB  - BACKGROUND: The information on the risk of thromboembolism (TE) in inflammatory 
      bowel disease (IBD) and its predictors are lacking, especially from developing 
      countries. The present study evaluated the prevalence, predictors, and prognosis 
      of TE in IBD. METHODS: This case-control study included 35 patients with IBD 
      (ulcerative colitis [UC, n = 25]; Crohn's disease [CD], n = 10) and history of 
      TE, from a cohort of 3597 patients (UC n = 2752, CD n = 845) under follow-up from 
      2005 to 2018. Details on demographics, extraintestinal manifestations (EIMs), 
      patient status, type and outcomes of TE, treatment details, and disease course 
      were compared with IBD patients without TE (age, gender, and duration of 
      follow-up matched) in the ratio of 1:4. RESULTS: Prevalence of TE in IBD was 0.9% 
      (UC-0.89%, CD-1.2%). Among TE patients (mean age: 34.9 +/- 13.1 years, 48.6% 
      males), median duration from diagnosis to TE was 12 (inter-quartile range [IQR]: 
      3-36) months, 37% had other EIMs, 94.1% had moderate/severe disease at time of 
      TE, 62.8% had steroid-dependent/refractory disease, and 5 patients (14.2%) died 
      because of disease-related complications. Lower limb was the commonest site 
      (57.1%), 14.3% had pulmonary TE, and 31.4% had involvement of multiple sites. 
      Phenotypically, more patients with TE (among UC) had steroid-dependent disease 
      (60% vs. 25%, p = 0.001), pancolitis (76% vs. 36%, p = 0.002), chronic continuous 
      disease course (44% vs. 19%, p = 0.009), and acute severe colitis (48% vs. 18%, 
      p = 0.002), of which the latter three were also independent predictors of TE. 
      CONCLUSION: Approximately 1% of patients with IBD develop thromboembolism 
      relatively early during their disease course, and TE is associated with severe 
      disease and higher disease-related complications including mortality.
CI  - (c) 2022. Indian Society of Gastroenterology.
FAU - S, Yadukrishna
AU  - S Y
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Kedia, Saurabh
AU  - Kedia S
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Teja, Varun
AU  - Teja V
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Vuyyuru, Sudheer Kumar
AU  - Vuyyuru SK
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Yadav, Nidhi
AU  - Yadav N
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Sahu, Pabitra
AU  - Sahu P
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Jain, Saransh
AU  - Jain S
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Yadav, Dawesh P
AU  - Yadav DP
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Bopanna, Sawan
AU  - Bopanna S
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Mouli, Venigalla Pratap
AU  - Mouli VP
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Madhu, Deepak
AU  - Madhu D
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Sharma, Raju
AU  - Sharma R
AD  - Department of Radiology, All India Institute of Medical Sciences, New Delhi, 110 
      029, India.
FAU - Das, Prasenjit
AU  - Das P
AD  - Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110 
      029, India.
FAU - Makharia, Govind
AU  - Makharia G
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India.
FAU - Ahuja, Vineet
AU  - Ahuja V
AUID- ORCID: 0000-0002-5474-9709
AD  - Department of Gastroenterology, All India Institute of Medical Sciences, New 
      Delhi, 110 029, India. vineet.aiims@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220905
PL  - India
TA  - Indian J Gastroenterol
JT  - Indian journal of gastroenterology : official journal of the Indian Society of 
      Gastroenterology
JID - 8409436
RN  - 0 (Steroids)
SB  - IM
CIN - Indian J Gastroenterol. 2022 Aug;41(4):321-324. PMID: 36087212
MH  - Adult
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - *Colitis
MH  - *Colitis, Ulcerative/epidemiology
MH  - *Crohn Disease/epidemiology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - *Inflammatory Bowel Diseases/complications
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Steroids
MH  - *Thromboembolism/complications
MH  - Young Adult
OTO - NOTNLM
OT  - Crohn's disease
OT  - Mortality
OT  - Steroids
OT  - Thromboembolism
OT  - Ulcerative colitis
EDAT- 2022/09/06 06:00
MHDA- 2022/10/06 06:00
CRDT- 2022/09/05 11:21
PHST- 2020/07/08 00:00 [received]
PHST- 2021/12/22 00:00 [accepted]
PHST- 2022/09/06 06:00 [pubmed]
PHST- 2022/10/06 06:00 [medline]
PHST- 2022/09/05 11:21 [entrez]
AID - 10.1007/s12664-021-01237-w [pii]
AID - 10.1007/s12664-021-01237-w [doi]
PST - ppublish
SO  - Indian J Gastroenterol. 2022 Aug;41(4):325-335. doi: 10.1007/s12664-021-01237-w. 
      Epub 2022 Sep 5.