PMID- 36065447
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220914
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with 
      small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report.
PG  - 952868
LID - 10.3389/fimmu.2022.952868 [doi]
LID - 952868
AB  - Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a 
      reversible inhibition of ion channel actions by autoantibodies and is associated 
      with a relatively good prognosis. Pathological findings of NMDAR encephalitis 
      usually do not show neurophagorous nodules, but rare or mild inflammatory 
      infiltration. We report a patient of small cell lung cancer (SCLC)-related 
      paraneoplastic encephalitis with NMDAR antibodies, a cytotoxic T-cell-mediated 
      pathology of the brain, and a rapid clinical course. This case highlights that 
      the neuropathological diversity of NMDAR encephalitis may be even broader than 
      previously thought and that NMDAR antibodies may also be found in various 
      pathological conditions with a vigorous immune response.
CI  - Copyright (c) 2022 Akanuma, Iizuka, Abe, Yoshida, Matsuda, Sugimoto, Hashimoto and 
      Kanai.
FAU - Akanuma, Haruna
AU  - Akanuma H
AD  - Department of Neurology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Iizuka, Takahiro
AU  - Iizuka T
AD  - Department of Neurology, Kitasato University School of Medicine, Sagamihara, 
      Japan.
FAU - Abe, Dan
AU  - Abe D
AD  - Department of Neurology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Yoshida, Kenji
AU  - Yoshida K
AD  - Department of Neurology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Matsuda, Nozomu
AU  - Matsuda N
AD  - Department of Neurology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Sugimoto, Kotaro
AU  - Sugimoto K
AD  - Department of Pathology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Hashimoto, Yuko
AU  - Hashimoto Y
AD  - Department of Pathology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
FAU - Kanai, Kazuaki
AU  - Kanai K
AD  - Department of Neurology, Fukushima Medical University School of Medicine, 
      Fukushima, Japan.
LA  - eng
PT  - Case Reports
DEP - 20220819
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications/etiology
MH  - Autoantibodies
MH  - Humans
MH  - *Lung Neoplasms/complications
MH  - Receptors, N-Methyl-D-Aspartate
MH  - *Small Cell Lung Carcinoma/complications
MH  - T-Lymphocytes, Cytotoxic
PMC - PMC9440277
OTO - NOTNLM
OT  - Anti-N-methyl-d-aspartate receptor antibodies
OT  - cytotoxic T-cells
OT  - paraneoplastic encephalitis
OT  - pathology
OT  - small cell lung cancer
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/07 06:00
MHDA- 2022/09/09 06:00
PMCR- 2022/01/01
CRDT- 2022/09/06 01:51
PHST- 2022/05/25 00:00 [received]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/09/06 01:51 [entrez]
PHST- 2022/09/07 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.952868 [doi]
PST - epublish
SO  - Front Immunol. 2022 Aug 19;13:952868. doi: 10.3389/fimmu.2022.952868. eCollection 
      2022.