PMID- 36065542
OWN - NLM
STAT- MEDLINE
DCOM- 20220907
LR  - 20220907
IS  - 1952-4013 (Electronic)
IS  - 1167-1122 (Linking)
VI  - 32
IP  - 3
DP  - 2022 May 1
TI  - Intravenous immunoglobulin-induced thrombocytopenia: a case report and review of 
      the literature.
PG  - 373-376
LID - 10.1684/ejd.2022.4271 [doi]
AB  - BACKGROUND: Intravenous immunoglobulin (IVIG), a pooled blood product acquired 
      from multiple healthy donors, is an effective treatment for various types of 
      autoimmune diseases, haematological disorders, and infectious diseases. Adverse 
      haematological events such as throm-bocytopenia are rarely caused by IVIG. 
      OBJECTIVES: To investigate the phenomenon of IVIG-induced thrombocytopenia. 
      MATERIALS & METHODS: A case study and a review of the previous literature based 
      on a search using MEDLINE (PubMed) and ICHUSHI (for Japanese literature) 
      electronic databases. RESULTS: The present case of dermatomyositis exhibited two 
      episodes of IVIG-induced thrombocytopenia, which occurred a few days after 
      initiating IVIG and was significant within two weeks without haemorrhagic 
      symptoms. Spontaneous remission of thrombocytopenia was repeatedly observed. 
      Based on a review of five cases, the underlying disorders were autoimmune bullous 
      diseases in three of the five cases. Polyethylene glycol-treated human 
      immunoglobulin products were used in three of the five cases. The clinical course 
      of IVIG-induced thrombocytopenia was similar to that in our present case. 
      CONCLUSION: Because of the rarity of severe haemorrhagic symptoms and spontaneous 
      remission of IVIG-induced thrombocytopenia, discontinuation of IVIG due to 
      thrombocytopenia is not straightforward.
FAU - Fukuzono, Maki
AU  - Fukuzono M
AD  - Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575, Japan
FAU - Okiyama, Naoko
AU  - Okiyama N
AD  - Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575, Japan
AD  - Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo 
      Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
FAU - Iwasaki, Riko
AU  - Iwasaki R
AD  - Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575, Japan
FAU - Endo, Ruriko
AU  - Endo R
AD  - Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575, Japan
FAU - Sasaki, Katsuhito
AU  - Sasaki K
AD  - Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575, Japan
FAU - Inoue, Sae
AU  - Inoue S
AD  - Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575, Japan
FAU - Nomura, Toshifumi
AU  - Nomura T
AD  - Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 
      Tennodai, Tsukuba, Ibaraki 305-8575, Japan
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
TT  - Intravenous immunoglobulin-induced thrombocytopenia: a case report and review of 
      the literature.
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - *Autoimmune Diseases
MH  - Humans
MH  - Immunoglobulins, Intravenous/therapeutic use
MH  - Remission, Spontaneous
MH  - *Skin Diseases, Vesiculobullous/chemically induced
MH  - *Thrombocytopenia/chemically induced/drug therapy
OTO - NOTNLM
OT  - adverse event
OT  - intravenous immunoglobulin
OT  - thrombocytopenia
EDAT- 2022/09/07 06:00
MHDA- 2022/09/08 06:00
CRDT- 2022/09/06 03:01
PHST- 2022/09/06 03:01 [entrez]
PHST- 2022/09/07 06:00 [pubmed]
PHST- 2022/09/08 06:00 [medline]
AID - 10.1684/ejd.2022.4271 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2022 May 1;32(3):373-376. doi: 10.1684/ejd.2022.4271.