PMID- 36066197
OWN - NLM
STAT- MEDLINE
DCOM- 20230712
LR  - 20230718
IS  - 1528-1140 (Electronic)
IS  - 0003-4932 (Linking)
VI  - 278
IP  - 2
DP  - 2023 Aug 1
TI  - Cholecystectomy Increases the Risk of Type 2 Diabetes in the Korean Population: 
      Data From the National Health Insurance Cooperation Health Checkup 2010-2017.
PG  - e264-e271
LID - 10.1097/SLA.0000000000005683 [doi]
AB  - OBJECTIVE: This study assessed whether cholecystectomy is a risk factor for newly 
      developed type 2 diabetes mellitus (T2DM) in the Korean population. BACKGROUND: 
      There is a lack of evidence that cholecystectomy is independently associated with 
      insulin resistance and T2DM. METHODS: This study included all patients aged more 
      than 20 years who had undergone cholecystectomy from 2010 to 2015 (n=55,166) and 
      age-matched and sex-matched control subjects without cholecystectomy (n=110,332) 
      using the National Health Insurance Service database. They were followed up until 
      the date of newly developed T2DM or study end and the incidence of T2DM was 
      traced over a maximum observation period of 7 years. RESULTS: Overall, 55,166 
      patients who underwent cholecystectomy and 110,332 age-matched and sex-matched 
      controls were followed up for  approximately 4.7 years, during which, incident T2DM occurred in 
      5982 (3.61%) patients. Cholecystectomy was associated with 20% higher risk of 
      T2DM after adjustment for all covariates. The cumulative incidence of T2DM also 
      significantly increased in the cholecystectomy group for  approximately 7 years ( P <0.001). 
      The adjusted hazard ratio (HR) for T2DM was the highest in the group with both 
      cholecystectomy and obesity using the control without both cholecystectomy and 
      obesity as a reference [HR=1.41, 95% confidence interval (CI): 1.29-1.56]. The 
      group with cholecystectomy without obesity showed the comparable risk of incident 
      T2DM compared with the group without cholecystectomy with obesity (HR=1.29, 95% 
      CI: 1.20-1.40 for cholecystectomy without obesity and HR=1.24, 95% CI: 1.14-1.36 
      for control with obesity). CONCLUSIONS: These results provide evidence that 
      cholecystectomy is associated with an increased risk of newly developed T2DM in 
      the Korean population. Further research is required to elucidate the mechanism of 
      the association between cholecystectomy and incident diabetes.
CI  - Copyright (c) 2022 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Huh, Ji Hye
AU  - Huh JH
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Lee, Kyong Joo
AU  - Lee KJ
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Cho, Yun Kyung
AU  - Cho YK
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine, Seoul, Republic of Korea.
AD  - Asan Diabetes Center, Asan Medical Center, Seoul, Republic of Korea.
FAU - Moon, Shinje
AU  - Moon S
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Kim, Yoon Jung
AU  - Kim YJ
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Roh, Eun
AU  - Roh E
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Han, Kyung-do
AU  - Han KD
AD  - Department of Statistics and Actuarial Science, Soongsil University, Seoul, 
      Republic of Korea.
FAU - Koh, Dong Hee
AU  - Koh DH
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Kang, Jun Goo
AU  - Kang JG
AUID- ORCID: 0000-0001-9523-7251
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Lee, Seong Jin
AU  - Lee SJ
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Ihm, Sung-Hee
AU  - Ihm SH
AD  - Department of Internal Medicine, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220905
PL  - United States
TA  - Ann Surg
JT  - Annals of surgery
JID - 0372354
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/epidemiology/complications
MH  - Risk Factors
MH  - Obesity/complications
MH  - Cholecystectomy/adverse effects
MH  - Republic of Korea/epidemiology
MH  - Incidence
COIS- The authors report no conflicts of interest.
EDAT- 2022/09/07 06:00
MHDA- 2023/07/12 06:42
CRDT- 2022/09/06 08:43
PHST- 2023/07/12 06:42 [medline]
PHST- 2022/09/07 06:00 [pubmed]
PHST- 2022/09/06 08:43 [entrez]
AID - 00000658-202308000-00032 [pii]
AID - 10.1097/SLA.0000000000005683 [doi]
PST - ppublish
SO  - Ann Surg. 2023 Aug 1;278(2):e264-e271. doi: 10.1097/SLA.0000000000005683. Epub 
      2022 Sep 5.