PMID- 36066198
OWN - NLM
STAT- MEDLINE
DCOM- 20221103
LR  - 20230205
IS  - 1755-5949 (Electronic)
IS  - 1755-5930 (Print)
IS  - 1755-5930 (Linking)
VI  - 28
IP  - 12
DP  - 2022 Dec
TI  - The therapeutic potential of bone marrow-derived macrophages in neurological 
      diseases.
PG  - 1942-1952
LID - 10.1111/cns.13964 [doi]
AB  - Circulating monocytes are precursors of both tissue macrophages and dendritic 
      cells, and they can infiltrate the central nervous system (CNS) where they 
      transform into bone marrow-derived macrophages (BMDMs). BMDMs play essential 
      roles in various CNS diseases, thus modulating BMDMs might be a way to treat 
      these disorders because there are currently no efficient therapeutic methods 
      available for most of these neurological diseases. Moreover, BMDMs can serve as 
      promising gene delivery vehicles following bone marrow transplantation for 
      otherwise incurable genetic CNS diseases. Understanding the distinct roles that 
      BMDMs play in CNS diseases and their potential as gene delivery vehicles may 
      provide new insights and opportunities for using BMDMs as therapeutic targets or 
      delivery vehicles. This review attempts to comprehensively summarize the 
      neurological diseases that might be treated by modulating BMDMs or by delivering 
      gene therapies via BMDMs after bone marrow transplantation.
CI  - (c) 2022 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & 
      Sons Ltd.
FAU - Zhou, Kai
AU  - Zhou K
AUID- ORCID: 0000-0003-1026-757X
AD  - Henan Neurodevelopment Engineering Research Center for Children, Children's 
      Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
FAU - Han, Jinming
AU  - Han J
AUID- ORCID: 0000-0002-6084-3275
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
FAU - Wang, Yafeng
AU  - Wang Y
AD  - Henan Neurodevelopment Engineering Research Center for Children, Children's 
      Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
AD  - Department of Hematology and Oncology, Children's Hospital Affiliated to 
      Zhengzhou University, Henan, Children's Hospital, Zhengzhou Children's Hospital, 
      Zhengzhou, China.
FAU - Xu, Yiran
AU  - Xu Y
AD  - Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research 
      Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou 
      University, Zhengzhou, China.
FAU - Zhang, Yaodong
AU  - Zhang Y
AD  - Henan Neurodevelopment Engineering Research Center for Children, Children's 
      Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
FAU - Zhu, Changlian
AU  - Zhu C
AUID- ORCID: 0000-0002-5029-6730
AD  - Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research 
      Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou 
      University, Zhengzhou, China.
AD  - Centre for Brain Repair and Rehabilitation, Institute of Neuroscience and 
      Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220906
PL  - England
TA  - CNS Neurosci Ther
JT  - CNS neuroscience & therapeutics
JID - 101473265
SB  - IM
MH  - Humans
MH  - *Macrophages
MH  - Central Nervous System
MH  - Monocytes
MH  - Bone Marrow Transplantation
MH  - *Central Nervous System Diseases
PMC - PMC9627381
OTO - NOTNLM
OT  - bone marrow transplantation
OT  - dysfunctional microglia
OT  - gene delivery
OT  - gene therapy
OT  - macrophage
OT  - monocyte
COIS- The authors declare no competing interest.
EDAT- 2022/09/07 06:00
MHDA- 2022/11/04 06:00
PMCR- 2022/09/06
CRDT- 2022/09/06 08:43
PHST- 2022/08/19 00:00 [revised]
PHST- 2022/05/30 00:00 [received]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/09/07 06:00 [pubmed]
PHST- 2022/11/04 06:00 [medline]
PHST- 2022/09/06 08:43 [entrez]
PHST- 2022/09/06 00:00 [pmc-release]
AID - CNS13964 [pii]
AID - 10.1111/cns.13964 [doi]
PST - ppublish
SO  - CNS Neurosci Ther. 2022 Dec;28(12):1942-1952. doi: 10.1111/cns.13964. Epub 2022 
      Sep 6.