PMID- 36066311
OWN - NLM
STAT- MEDLINE
DCOM- 20221027
LR  - 20221027
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 34
IP  - 43
DP  - 2022 Oct
TI  - Puffball-Inspired Microrobotic Systems with Robust Payload, Strong Protection, 
      and Targeted Locomotion for On-Demand Drug Delivery.
PG  - e2204791
LID - 10.1002/adma.202204791 [doi]
AB  - Microrobots are recognized as transformative solutions for drug delivery systems 
      (DDSs) because they can navigate through the body to specific locations and 
      enable targeted drug release. However, their realization is substantially limited 
      by insufficient payload capacity, unavoidable drug leakage/deactivation, and 
      strict modification/stability criteria for drugs. Natural puffballs possess 
      fascinating features that are highly desirable for DDSs, including a large 
      fruitbody for storing spores, a flexible protective cap, and environmentally 
      triggered release mechanisms. This report presents a puffball-inspired 
      microrobotic system which incorporates an internal chamber for loading large drug 
      quantities and spatial drug separation, and a near-infrared-responsive 
      top-sealing layer offering strong drug protection and on-demand release. These 
      puffball-inspired microrobots (PIMs) display tunable loading capacities up to 
      high concentrations and enhanced drug protection with minimal drug leakage. Upon 
      near-infrared laser irradiation, on-demand drug delivery with rapid release 
      efficiency is achieved. The PIMs also demonstrate translational motion 
      velocities, switchable motion modes, and precise locomotion under a rotating 
      magnetic field. This work provides strong proof-of-concept for a DDS that 
      combines the superior locomotion capability of microrobots with the unique 
      characteristics of puffballs, thereby illustrating a versatile avenue for 
      development of a new generation of microrobots for targeted drug delivery.
CI  - (c) 2022 The Authors. Advanced Materials published by Wiley-VCH GmbH.
FAU - Song, Xin
AU  - Song X
AUID- ORCID: 0000-0003-4017-9685
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
FAU - Sun, Rujie
AU  - Sun R
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
FAU - Wang, Richard
AU  - Wang R
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
FAU - Zhou, Kun
AU  - Zhou K
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
FAU - Xie, Ruoxiao
AU  - Xie R
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
FAU - Lin, Junliang
AU  - Lin J
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
FAU - Georgiev, Dimitar
AU  - Georgiev D
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
AD  - Department of Computing, UKRI Centre for Doctoral Training in AI for Healthcare, 
      Imperial College London, London, SW7 2AZ, UK.
FAU - Paraschiv, Andrei-Alexandru
AU  - Paraschiv AA
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
AD  - Department of Chemistry, Imperial College London, London, SW7 2AZ, UK.
FAU - Zhao, Ruibo
AU  - Zhao R
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
AD  - Institute of Smart Biomaterials, School of Materials Science and Engineering, 
      Zhejiang Sci-Tech University, Hangzhou, Zhejiang, 310018, China.
FAU - Stevens, Molly M
AU  - Stevens MM
AUID- ORCID: 0000-0002-1146-7090
AD  - Department of Materials, Department of Bioengineering, Institute of Biomedical 
      Engineering, Imperial College London, London, SW7 2AZ, UK.
LA  - eng
GR  - China Scholarship Council/
GR  - A2741/M873/Rosetrees Trust Young Enterprise Fellowship/
GR  - EP/S023283/1/UK Research and Innovation/
GR  - EP/P02520X/1/UK Research and Innovation/
GR  - CiET2021\94/Royal Academy of Engineering Chair in Emerging Technologies award/
PT  - Journal Article
DEP - 20220927
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
SB  - IM
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - *Phototherapy
MH  - Infrared Rays
MH  - Locomotion
OTO - NOTNLM
OT  - bioinspired systems
OT  - controlled release
OT  - intelligent microrobots
OT  - magnetic actuation
OT  - targeted therapy
EDAT- 2022/09/07 06:00
MHDA- 2022/10/28 06:00
CRDT- 2022/09/06 09:22
PHST- 2022/08/30 00:00 [revised]
PHST- 2022/05/27 00:00 [received]
PHST- 2022/09/07 06:00 [pubmed]
PHST- 2022/10/28 06:00 [medline]
PHST- 2022/09/06 09:22 [entrez]
AID - 10.1002/adma.202204791 [doi]
PST - ppublish
SO  - Adv Mater. 2022 Oct;34(43):e2204791. doi: 10.1002/adma.202204791. Epub 2022 Sep 
      27.