PMID- 36066333
OWN - NLM
STAT- MEDLINE
DCOM- 20230418
LR  - 20230627
IS  - 1937-3376 (Electronic)
IS  - 1937-3368 (Linking)
VI  - 29
IP  - 2
DP  - 2023 Apr
TI  - A Systematic Review of Bone Marrow Stromal Cells and Periosteum-Derived Cells for 
      Bone Regeneration.
PG  - 103-122
LID - 10.1089/ten.TEB.2022.0115 [doi]
AB  - Bone marrow stromal cells (BMSCs) and periosteum-derived cells (PDCs) represent 
      promising skeletal stem cell sources to treat critical-size bone defects. 
      However, the large number of preclinical tests with a variety of in vivo data 
      complicates the selection of cells for further clinical translation. This 
      systematic review aims to analyze the in vivo bone-forming efficacy of BMSCs- and 
      PDCs-based approaches in all published preclinical experiments until November 
      2020. For this purpose, four databases (PubMed, Embase, Cochrane Central Register 
      of Controlled Trial, and Web of Science) were searched for eligible literature, 
      which yielded a total of 94 full-text articles for systematic review. This review 
      generated an evidence-based list of BMSC- or PDC-based approaches, which have 
      been evaluated for bone formation in different animal models. Among them, 74 
      studies were included for pairwise and network meta-analysis. The results 
      revealed that both PDC and BMSC had beneficial bone-forming efficacy compared to 
      bare scaffold. In addition, BMSC- and PDC-based approaches had no significant 
      difference regarding in vivo bone-forming efficacy. However, BMSC-based approach 
      had a higher probability to be ranked better than PDC-based approach. 
      Furthermore, the review discusses (i) the possible risk of bias of the in vivo 
      evaluation of cell-based approaches, (ii) the difficulty in replication of such 
      experiments due to frequent poor reporting of the methods and results, and (iii) 
      the clinical relevance of the currently utilized BMSC- and PDC-based approaches. 
      Systematic review registration: The study was prospectively registered in 
      PROSPERO, Registration No. CRD42021270922.
FAU - Zhu, Jingxian
AU  - Zhu J
AUID- ORCID: 0000-0003-0095-654X
AD  - The State Key Laboratory Breeding Base of Basic Sciences of Stomatology, Key 
      Laboratory of Oral Biomedicine, Ministry of Education (Hubei-MOST KLOS and 
      KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, China.
FAU - Xiong, Jiabi
AU  - Xiong J
AUID- ORCID: 0000-0003-0874-1738
AD  - The State Key Laboratory Breeding Base of Basic Sciences of Stomatology, Key 
      Laboratory of Oral Biomedicine, Ministry of Education (Hubei-MOST KLOS and 
      KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, China.
FAU - Ji, Wei
AU  - Ji W
AUID- ORCID: 0000-0002-1473-5222
AD  - The State Key Laboratory Breeding Base of Basic Sciences of Stomatology, Key 
      Laboratory of Oral Biomedicine, Ministry of Education (Hubei-MOST KLOS and 
      KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, China.
AD  - Department of Implantology, School and Hospital of Stomatology, Wuhan University, 
      Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20221011
PL  - United States
TA  - Tissue Eng Part B Rev
JT  - Tissue engineering. Part B, Reviews
JID - 101466660
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells
MH  - Bone Regeneration
MH  - *Mesenchymal Stem Cells
MH  - Models, Animal
MH  - Osteogenesis
MH  - *Periosteum
OTO - NOTNLM
OT  - bone marrow stromal cell
OT  - bone regeneration
OT  - cell-based approach
OT  - network meta-analysis
OT  - periosteum-derived cell
OT  - systematic review
EDAT- 2022/09/07 06:00
MHDA- 2023/04/12 06:42
CRDT- 2022/09/06 09:42
PHST- 2023/04/12 06:42 [medline]
PHST- 2022/09/07 06:00 [pubmed]
PHST- 2022/09/06 09:42 [entrez]
AID - 10.1089/ten.TEB.2022.0115 [doi]
PST - ppublish
SO  - Tissue Eng Part B Rev. 2023 Apr;29(2):103-122. doi: 10.1089/ten.TEB.2022.0115. 
      Epub 2022 Oct 11.