PMID- 36066914
OWN - NLM
STAT- MEDLINE
DCOM- 20221024
LR  - 20221024
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 86
IP  - 11
DP  - 2022 Oct 20
TI  - Pro-angiogenic activity of isofuran.
PG  - 1506-1514
LID - 10.1093/bbb/zbac146 [doi]
AB  - Isofurans (IsoFs) are a series of novel discovered lipid peroxidation products. 
      This study focused on the investigation of the angiogenic property of IsoF. MTT 
      stain assay indicated that 1 microm IsoF had the most bioactivity in rat brain 
      endothelial cells (RBECs). IsoF significantly promoted cellular proliferation and 
      migration and remarkably decreased staurosporine-induced apoptosis by TUNEL assay 
      in the RBECs. It successfully up-regulated rat aortic vascularization and choroid 
      explant sprouting, extracellular regulated protein kinases (ERK)1/2, and 
      triggered calcium release. RT-PCR examination indicated that IsoF up-regulated 
      tumor necrosis factor (TNF)alpha, angiopoietin-1 receptor (Tie2), and vascular 
      endothelial growth factor (VEGF)-A, but did not interfere with caspase 2 and 
      VEGF-C in the RBECs. IsoF has pro-angiogenic activity. Calcium release and ERK1/2 
      phosphorylation may be involved in the signaling of the IsoF-induced 
      up-regulation of TNFalpha, Tie2, and VEGF-A, which could be the molecular mechanism 
      of the pro-angiogenic activity of the IsoF.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of Japan 
      Society for Bioscience, Biotechnology, and Agrochemistry.
FAU - Zhang, Jingxia
AU  - Zhang J
AD  - Key Laboratory of Translational Tumor Medicine in Fujian Province, School of 
      Basic Medical Science Putian University, Putian, Fujian, China.
FAU - Wang, Xiangjiang
AU  - Wang X
AD  - Key Laboratory of Translational Tumor Medicine in Fujian Province, School of 
      Basic Medical Science Putian University, Putian, Fujian, China.
FAU - Lin, Zhiping
AU  - Lin Z
AD  - Key Laboratory of Translational Tumor Medicine in Fujian Province, School of 
      Basic Medical Science Putian University, Putian, Fujian, China.
FAU - Zhu, Tang
AU  - Zhu T
AUID- ORCID: 0000-0003-3237-0420
AD  - Key Laboratory of Translational Tumor Medicine in Fujian Province, School of 
      Basic Medical Science Putian University, Putian, Fujian, China.
AD  - Yujia Biotech., Guangzhou, Guangdong, China.
LA  - eng
GR  - 2 019 119/Putian University Science and Technology Project/
PT  - Journal Article
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Angiopoietin-1)
RN  - 0 (Vascular Endothelial Growth Factor C)
RN  - EC 3.4.22.- (Caspase 2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - SY7Q814VUP (Calcium)
RN  - H88EPA0A3N (Staurosporine)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Vascular Endothelial Growth Factor A/metabolism
MH  - *Angiopoietin-1/genetics
MH  - Vascular Endothelial Growth Factor C
MH  - Caspase 2
MH  - Endothelial Cells/metabolism
MH  - Tumor Necrosis Factor-alpha
MH  - Calcium/metabolism
MH  - Staurosporine
MH  - Neovascularization, Physiologic
OTO - NOTNLM
OT  - Lipid peroxidative products
OT  - angiogenesis
OT  - isofuran
OT  - rat brain endothelial cells
EDAT- 2022/09/07 06:00
MHDA- 2022/10/25 06:00
CRDT- 2022/09/06 11:43
PHST- 2022/06/05 00:00 [received]
PHST- 2022/08/29 00:00 [accepted]
PHST- 2022/09/07 06:00 [pubmed]
PHST- 2022/10/25 06:00 [medline]
PHST- 2022/09/06 11:43 [entrez]
AID - 6692914 [pii]
AID - 10.1093/bbb/zbac146 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2022 Oct 20;86(11):1506-1514. doi: 
      10.1093/bbb/zbac146.